Pharmacological properties of the drug Dalatsin vaginal cream
Clindamycin is an antimicrobial agent that is effective against infections caused by sensitive strains of anaerobic as well as gram-positive aerobic bacteria. In vitro active against microorganisms that cause bacterial vaginosis - Gardnerella vaginalis; Mobiluncus spp; Bacteroides spp; Mycoplasma hominis; Peptostreptococcus spp. Does not affect Trichomonas vaginalis and Candida albicans. Cross-resistance of microorganisms to clindamycin and lincomycin was noted. In healthy volunteers, following intravaginal administration of 100 mg clindamycin phosphate once daily at a concentration equivalent to 20 mg clindamycin per 1 g cream, peak serum clindamycin concentrations averaged 20 ng/mL (range, 3–93 ng/mL). Approximately 3% (0.1–7.0%) of the administered dose is absorbed systemically. In women with bacterial vaginosis, after vaginal injection of 5 g of clindamycin phosphate cream (clindamycin 20 mg/g), the amount of clindamycin absorbed is 4% (0.8–8.0%), which is approximately the same as in healthy volunteers.
Analogs
Level 4 ATC code matches:
Zinerite
Zerkalin
Erythromycin ointment
Klindovit
Erythromycin
and Clindatop gel , Clindacin suppositories , Clindacin cream , Clindes , Clindamycin , Clindamycin capsules .
Side effects of the drug Dalatsin vaginal cream
The safety of the drug was studied in clinical studies in both non-pregnant and pregnant patients in the second and third trimester of pregnancy. The following side effects associated with the use of the drug were identified (observed in less than 10% of patients): vaginal candidiasis; irritation of the vulva and vagina; vulvovaginitis; vaginitis caused by Trichomonas vaginalis; menstrual disorders; vaginal pain; metrorrhagia; dysuria; vaginal discharge; urinary tract infections; pathological childbirth; endometriosis; glucosuria and proteinuria. Dizziness and headache were also noted; heartburn, nausea, vomiting, diarrhea, constipation, abdominal pain; allergic reactions (rash, urticaria); candidiasis; fungal infections; generalized or localized abdominal pain; bacterial infections; pain in the pelvic area; bad breath; upper respiratory tract infections; pain throughout the body; backache; abnormalities in microbiological tests.
Reviews about Dalatsin
Quite often there are reviews about Dalatsin T gel and it must be said that they are polar. Some people praise this acne gel and note its effectiveness, it does not dry out the skin, eliminates oily shine, removes acne and characterize it as an excellent product.
“It became a salvation,” “dalacin doesn’t help right away.” But many users say that it has a weak effect and high cost compared to analogues.
Many women had to deal with Dalatsin vaginal cream and suppositories when treating vaginitis. Reviews about Dalatsin candles are mostly positive. Women note a good therapeutic effect and ease of use (using an applicator). However, everyone notes a slight burning sensation in the vagina after inserting a suppository.
Reviews for Dalacin cream are mostly negative. First of all, there is a lack of a pronounced effect, a strong burning sensation when administering the cream, and a high cost. “I was treated for a week - there was no result”, “...Dalacin cream did not help me - at first there was an improvement, but after 3 days everything fell into place again”, “caused severe irritation and pain.” Many women prefer Metrogyl .
Special instructions for the use of Dalatsin vaginal cream
Before starting treatment, it is necessary to laboratory exclude the presence of pathogenic microflora that are insensitive to the drug - Trichomonas vaginalis, Chlamydia trachomatis, N. gonorrhoeae, Candida albicans and Herpes simplex virus . The use of clindamycin may lead to excessive growth of microorganisms that are not sensitive to it, especially yeast. Diarrhea and cases of pseudomembranous colitis have been reported with the use of almost all antibiotics. In case of severe or prolonged diarrhea, the drug should be discontinued (even despite its minimal amount absorbed after intravaginal use) and, if necessary, appropriate diagnostic and therapeutic measures should be taken. According to clinical trials, intravaginal use of clindamycin phosphate cream in pregnant women in the second trimester, as well as systemic use of clindamycin in the second and third trimester, did not lead to any pathological effects. No adequate and well-controlled studies have been conducted in the first trimester of pregnancy, so during this period the drug should be used only if there are compelling indications. It is unknown whether clindamycin is excreted in breast milk after intravaginal use of clindamycin phosphate. However, clindamycin has been reported to pass into breast milk after oral or parenteral administration, which must be taken into account when considering prescribing the drug during breastfeeding.
Overdose
There are no cases of overdose when taking recommended doses orally. When anaphylactic reactions occur, glucocorticosteroids and antihistamines . There is no antidote. Hemodialysis is ineffective.
There are also no reports of overdose of intravaginal cream and suppositories. Systemic reactions may occur: diarrhea , including hemorrhagic , pseudomembranous colitis . Symptomatic therapy is carried out.
Drug interactions Dalatsin vaginal cream
There is cross-resistance between clindamycin and lincomycin. Antagonism between clindamycin and erythromycin has been demonstrated in vitro No interactions were observed in pharmacodynamic, pharmacokinetic or clinical studies. There is no information on the use of other drugs in combination with clindamycin phosphate cream. Vaginal cream contains mineral oil, which may reduce the strength of products made from latex or rubber, such as condoms or vaginal contraceptive diaphragms. Therefore, the use of these products during treatment with the drug is not recommended.
Indications for use
Dalatsin suppositories and vaginal cream: bacterial vaginitis .
Gel Dalatsin T: treatment of acne , folliculitis , staphyloderma .
Dalacin C capsules and solution:
- otitis , sinusitis , pneumonia , lung abscess , complicated bronchitis ;
- furunculosis , acne, abscesses, erysipelas , osteomyelitis , infected wounds, purulent arthritis ;
- endometritis , colpitis , salpingitis ;
- abdominal abscesses, endocarditis , septicemia, peritonitis ;
- periodontitis and periodontal abscess ;
- malaria;
- prevention of endocarditis , infections during surgical interventions.
Dalatsin price, where to buy
You can purchase drugs in pharmacies in Russian cities and other countries. The price of Dalatsin cream 20 g is 529-614 rubles. The price of Dalatsin suppositories ranges from 552-653 rubles, and the price of Dalatsin T gel is 675-826 rubles. Tablets (capsules) are currently not available in Russian pharmacies.
Buying gel in Minsk is also problematic.
- Online pharmacies in RussiaRussia
- Online pharmacies in UkraineUkraine
- Online pharmacies in KazakhstanKazakhstan
LuxPharma* special offer
- Dalacin C phosphate solution for intravenous and intramuscular administration 300 mg/2ml amp.
1 piece 1660 rub. order - Dalacin C capsules 300 mg N16
2900 rub. order
ZdravCity
- Dalatsin vaginal suppositories 100 mg 3 pcs.Pharmacia & Upjohn
RUR 764 order
- Dalatsin gel 1% 30gPharmacia & Upjohn
1105 rub. order
Pharmacy Dialogue
- Dalatsin gel (tube 1% 30g)Pharmacia & Upjohn Company
RUB 1,017 order
- Dalatsin (sup. vag. 100 mg No. 3)Upjohn/Pfizer
RUR 777 order
- Dalatsin (supp. vag. 100 mg No. 3)Pharmacia & Upjohn Company
RUR 756 order
- Dalacin vaginal cream (tube 2% 40g)Pharmacia & Upjohn Company
RUB 863 order
- Dalatsin gel (tube 1% 30g)Pharmacia & Upjohn Company
RUB 1,033 order
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Pharmacy24
- Dalacin C Phosphate 600 mg 4 ml N1 solution for injection
328 UAH. order - Dalacin C 300 mg N16 capsules Fareva Amboise, France
393 UAH. order
- Dalacin C Phosphate 300 mg 2 ml No. 1 injection solution
198 UAH order
- Dalatsin 100 mg No. 3 suppositories Pharmacy i Upjohn Company, USA
294 UAH order
- Dalacin C 150 mg N16 capsules Fareva Amboise, France
295 UAH order
PaniPharmacy
- Dalacin C capsule Dalacin C capsules 300 mg No. 16 Belgium, Pharmacia
391 UAH. order
- Dalacin C ampoule Dalacin C phosphate 300 mg amp. 2ml No. 1 Belgium, Pfizer Manufacturing Belgium
202 UAH. order
- Dalacin cream Dalacin vaginal cream 2% 20g, Pharmacia & Upjohn
578 UAH order
- Dalacin C ampoule Dalacin C phosphate 600 mg ampoule 4 ml N1 Belgium, Pfizer Manufacturing Belgium
345 UAH. order
- Dalacin C ampoule Dalacin C phosphate solution for injection 150 mg/ml ampoule 4 ml Belgium, Pfizer Manufacturing Belgium
364 UAH order
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