Klenzit-C microspheres

Pimples and acne are a problem in modern society associated with poor environment, bad habits, exposure to ultraviolet radiation and poor diet.

Many cosmetic products only mask defects or are short-lived and stop after you stop using the product.

The drug Klenzit comes to the rescue . In this article we will look at the effect of the drug and find out which is better Klenzit or Klenzit S.

Important! Before using the drug, be sure to read the instructions and check whether you have any contraindications.

Comparison of the effectiveness of Klindovit and Klenzit

The effectiveness of Clindovit is quite similar to Klenzit - this means that the ability of the medicinal substance to provide the maximum possible effect is similar.
For example, if the therapeutic effect of Klindovit is more pronounced, then using Klenzit even in large doses will not achieve this effect.

Also, the speed of therapy - an indicator of the speed of therapeutic action - is approximately the same for Klindovit and Klenzit. And bioavailability, that is, the amount of a drug reaching its site of action in the body, is similar. The higher the bioavailability, the less it will be lost during absorption and use by the body.

EXPERIENCE OF USING KLENSIT "S" GEL AND KLENSITE IN THE THERAPY OF ACNE Shishkina N.P., Protsenko V.N. Federal State Health Institution Medical Unit No. 97 FMBA of Russia, Voronezh INTRODUCTION.
Acne is one of the most common skin diseases. The incidence of acne in medical unit No. 97 by age group is as follows: 17 – 24 years –78%; 25 – 34 years old – 9%; 35 – 44 years old – 4%. Severe forms of acne occur in 18% of patients, and scars form in 22%. The development and course of dermatoses largely depends on family (genetic) predisposition. When collecting a family history, it was revealed that the more often acne occurs in relatives and the more severe it is, the more severe the course is observed in the offspring. Hereditary predisposition was identified in 68% of acne cases. The development of acne lesions in the face and neck reduces the quality of life of acne patients. All patients experience a feeling of anxiety, restlessness and irritability, which reduces the patients’ activity in social life. Patients with acne have reduced resistance to life's difficulties. Patients with acne note self-doubt, indecision, difficulty in establishing interpersonal relationships, which leads to limited communication with others and isolation. Often severe forms of acne are associated with endocrine pathology. Thus, late hyperandrogenic acne in women is more common with polycystic ovary syndrome, congenital dysfunction of the adrenal root. OBJECTIVE OF THE STUDY: to study the effectiveness of the drug Klenzit to improve the quality of life and emotional sphere of patients with this pathology. MATERIAL AND METHODS. In a study of microbial flora in 30 people with various forms of acne, the following predominated: Propionobacterium acnes - 22 patients (73.3%), Staphylococcus epidermidis - 17 (56.7%), Staphylococcus aureus - 9 (30%), viridans streptococcus - 2 (6.7%), pentostreptococcus - 2 (6.7%), yeast-like fungi - 6 (20%). As a result of these studies, it was found that in papulopustular and indurative forms of acne, the species composition of the microflora was limited to 2 - 4 microbial agents, in abscess and conglobate forms it reached 7. Propionobacterium acnes is most often found in acne, which confirms its important role in the development of the disease. The most common clinical form of acne is the papulopustular form (76% of patients). The basic drugs for this form of the disease are antibiotics for systemic and external use. The most important principles of rational antibiotic therapy are to prescribe a drug to which the pathogen is sensitive. A significant disadvantage of antibiotic therapy is the formation of resistance to them and the development of allergies. In this regard, in the medical unit, 30 patients were treated for acne with topical retinoids - the preparations klensit and klensit "C". Clensite (adapalene) acts on three parts of the pathogenesis of acne: regulates sebum secretion, has a pronounced anti-inflammatory and comedonoletic effect. Klenzit “C” contains, in addition to adapalene, clindomycin, which has a broad antibacterial effect. Complex therapy included: physiotherapy - D'Arsonval, cryomassage; external treatment - preparations Klenzit “S”, Klenzit. Special instructions are as follows. Avoid: 1. Staying in the sun. 2. Use of artificial ultraviolet radiation (solarium). 3. Do not use abrasive cosmetics (scrubs). 4. Do not use the gel to treat damaged skin and burns. 5. Do not use drying agents (those containing alcohol). 6. Avoid contact with eyes and mucous membranes. In the treatment of acne, initially, in case of a severe inflammatory reaction, Klenzit “S” was prescribed for 1 – 2 weeks. The drug was applied to clean skin once a day without rubbing. After a decrease in the pronounced inflammatory reaction, the drug Klenzit was prescribed. The study involved 30 people: 22 women and 8 men diagnosed with acne of moderate severity, papulopustular form. RESULTS. Complete clinical recovery - 21 patients (70%), significant improvement - 8 (26.6%), no effect - 1 (3.3%). Reduction of inflammatory elements in 64% of patients was observed after 20 days. Complete clinical recovery occurred after 6 weeks. In 33% of patients (10 people), after 7–9 days from the start of treatment, reactions characteristic of retinoids were observed: the appearance of erythema - 5 (50%), dryness - 3 (30%), burning - 1 (10%), moderate peeling — 1 (10%). These symptoms were self-limited; 3 patients were prescribed a moisturizer. CONCLUSION. 1. The preparations Klenzit “S” and Klenzit are an effective remedy in the treatment of acne. 2. The drugs Klenzit “S” and Klenzit should be used for acne as monotherapy and in combination with systemic therapy. 3. When treated with these drugs, minor adverse reactions are observed. ‹ Experience in the use of 1% Pimecrolimus cream in the treatment of organic forms of VitiligoUp Experience in the treatment of chronic recurrent vulvovaginal candidiasis ›

Comparison of the safety of Clindovit and Klenzit

The safety of a drug includes many factors.

At the same time, in Klindovit it is quite similar to Klenzit. It is important where the drug is metabolized: drugs are excreted from the body either unchanged or in the form of products of their biochemical transformations. Metabolism occurs spontaneously, but most often involves major organs such as the liver, kidneys, lungs, skin, brain and others. When assessing metabolism in Klindovit, as well as in Klenzit, we look at which organ is the metabolizing organ and how critical the effect on it is.

The risk-benefit ratio is when the prescription of a drug is undesirable, but justified under certain conditions and circumstances, with the obligatory observance of caution in use. At the same time, Clindovit does not have any risks when used, just like Klenzit.

Also, when calculating safety, it is taken into account whether only allergic reactions occur or possible dysfunction of the main organs. In other matters, as well as the reversibility of the consequences of using Klindovit and Klenzit.

Gel Klenzit: instructions for use

Indications for use - according to the instructions, Klenzit gel has only one indication - “acne”, but this requires clarification. In fact, the instructions are not written entirely correctly and do not correspond to the modern international classification. The term acne implies that the patient has only non-inflammatory elements of acne - such as whiteheads or blackheads (they are also called closed and open comedones).

As for acne, there are 2 types - in the form of pustules (with pus inside) and in the form of papules without pus. In this case, papules can disappear without a trace over time, or transform into pustules. In general, the term “acne” is a colloquial expression, and their correct name is “papulopustular form of acne.” So, we can use the drug Klenzit both for the treatment of acne and for the treatment of pimples. But in the latter case, we will combine it with other drugs.

Composition of the gel "Klenzit" (in terms of 1 g):

* A homogeneous white gel, packaged in tubes of 15 or 30 g.

→ Klenzit gel official instructions (PDF)

Pharmacological action of the drug Klenzit -

The pharmacological effect is due to the presence of “adapalene 0.1%”, which belongs to the 3rd generation topical retinoids. The retinoid adapalene in the composition of the drug has the following effects:

• Suppression of hypersecretion of the sebaceous glands - increased activity of the sebaceous glands is one of the main mechanisms for the formation of acne and pimples. Adapalene inhibits the activity of sebocytes - the cells of the sebaceous glands, which are responsible for the production of fatty secretions (sebum). From personal experience I can say that from the first days of use the skin becomes much less oily.

• Reduction of follicular hyperkeratosis – hyperkeratosis of the follicular epithelium is the second most important mechanism that leads to the formation of acne and pimples. This process consists of thickening the layers of keratinocytes and disrupting their desquamation into the lumen of the follicle. Adapalene enhances the differentiation of keratinocytes in the follicles and facilitates their desquamation, which leads to a reduction in hyperkeratosis. In addition, adapalene facilitates the exfoliation of dead cells of the stratum corneum of the epidermis.

• Comedolytic effect - adapalene has the property of dissolving the fatty substrate that makes up acne (comedones). This leads to the release of clogged hair follicles and the unhindered removal of sebum to the surface of the skin. It should be noted that the comedolytic effect of adapalene is much more pronounced than that of azelaic acid.

• Anti-inflammatory effect – adapalene inhibits “chemotaxis” and migration of neutrophils to hair follicles, which prevents the formation of papules and pustules (pimples). Chemotaxis and migration of neutrophils to the follicles are associated with the fact that the enzymes of the P. acnes bacteria break down triglycerides from the secretion of the sebaceous glands into free fatty acids (monoglycerides). The latter are not only terribly comedogenic, but also stimulate chemotaxis and migration of neutrophils to the follicles.

Comparison of addiction between Klindovit and Klenzit

Like safety, addiction also involves many factors that must be considered when evaluating a drug.

So, the totality of the values ​​of such parameters as “o syndrome” in Klindovit is quite similar to the similar values ​​in Klenzit. Withdrawal syndrome is a pathological condition that occurs after the cessation of intake of addictive or dependent substances into the body. And resistance is understood as initial immunity to a drug; in this it differs from addiction, when immunity to a drug develops over a certain period of time. The presence of resistance can only be stated if an attempt has been made to increase the dose of the drug to the maximum possible. At the same time, Klindovit’s “syndrome” values ​​are quite small, however, the same as Klenzit’s.

Who do we recommend Klenzit gel to?

This section is not our fabrications, but international protocols for the treatment of acne and pimples, which are described in detail in the most famous textbook on dermatology, Fitzpatrick's Dermatology.

• If you have acne – in this case, you will only have non-inflammatory elements (white or blackheads) on your facial skin. In this case, only monotherapy with Klenzit will be enough for you, but in addition, cleansers with salicylic acid or alpha hydroxy acids (24stoma.ru) will not hurt. The only thing we still want to warn you about is the side effects.
  The fact is that in patients with dry and/or sensitive skin, topical retinoids in the form of gels can highly likely lead to skin irritation (even more dryness, redness, itching or burning). Therefore, in these types of patients it is better to use adapalene cream rather than a gel. Clenzit is not available in cream form, so we can recommend either Differin cream or Adaklin cream, which also contain adapalene.

  → International acne treatment protocol

• If you have acne (papules and/or pustules) - in this case we will need combination therapy, which will differ depending on the predominance of papules or pustules. If you have mostly papules without pus, then we prescribe Klenzit gel once a day (in the evening before bed) + Baziron AS containing benzoyl peroxide once a day (in the morning). Benzoyl peroxide is an antimicrobial component.
  But if you have papules with pus, then the situation changes, and in this case we will definitely need an antibiotic in the treatment regimen. For papulopustular acne of mild to moderate severity, antibiotics are prescribed externally. And in this case, it would be better to prescribe not Klenzit, but the drug Klenzit-S (it contains adapalene 0.1% and the antibiotic clindamycin 1%) - we prescribe it once a day in the evening before bed. Plus, in the morning we again prescribe Baziron AS with benzoyl peroxide to the patient.

  If we have a severe form of acne, then in this case antibiotics are prescribed only orally. In this case, in addition to antibiotics (read about them at the link below), we will prescribe Clenzit gel once a day in the evening before bed, and in the morning we will again prescribe Baziron AS with benzoyl peroxide.

  → International acne treatment protocol

How to apply the drug correctly. What course of treatment?

Clenzit can only be applied externally, avoiding lips, eyes and mucous membranes. This is done only once a day (before bedtime). It is important that before applying the product you cleanse your skin with a mild cleanser and dry it well, because... Application to wet skin will immediately lead to irritation. The drug is applied in a thin layer to areas of the face affected by acne and pimples. The drug is quite economical, and one 30 g tube will last you a long time.

When you see the result, patients with oily skin will notice almost on the second day that their skin has become much less oily. As for acne, the first visible result will be noticeable no earlier than 4 weeks from the start of therapy. A satisfactory result should be expected no earlier than after 8 weeks. A good lasting result is the field of completing the full course, which should last at least 3 months.

If you have acne, then we have already said that combination therapy is needed. If you use only Clenzit alone, the improvement of your acne will occur slowly (see the time frame for acne). But with combination therapy, for example, “Klensit + benzoyl peroxide” or “Klensit + benzoyl peroxide + antibiotic”, we will see the first results within 10-14 days.

Comparison of side effects of Clindovit and Klenzit

Side effects or adverse events are any adverse medical event that occurs in a subject after administration of a drug.

Klindovit's side effects are almost the same as Klenzit's. They both have few side effects. This implies that the frequency of their occurrence is low, that is, the indicator of how many cases of an undesirable effect of treatment are possible and registered is low. The undesirable effect on the body, the strength of influence and the toxic effect of Clindovit are similar to Klenzit: how quickly the body recovers after taking it and whether it recovers at all.