Cosmetologist’s opinion: “Russian preparations for biorevitalization are absolutely competitive”

From this article you will learn:

• biorevitalization: what kind of procedure is it, reviews,
• photos of patients before and after,
• injection and non-injection techniques,
• how much does biorevitalization cost - price for 1 procedure (for 2022).

Facial biorevitalization is a procedure for intradermal injection of high concentrations of active substances, which can significantly improve the appearance of the skin, increase its elasticity, as well as achieve a lifting effect and reduce the depth of wrinkles. Most often, hyaluronic acid, vitamins, microelements, amino acids are used for this, and in older age - components for intensive skin lifting, for example, peptides, DNA-RNA complexes and DMAE.

The composition of the drug is selected individually for each patient. The age of the patient, the condition of the facial skin, and, what is very important, the type of skin aging are taken into account. For example, for fine-wrinkle and deformation types of aging, completely different drugs will be indicated. An important problem is the training of specialists. How often, for example, do mesotherapists tell patients that capillary mesotherapy must be done before administering biorevitalizants? But in many cases, the severity and duration of the biorevitalization effect will depend on this.

Biorevitalization: photo of the procedure

Indications for biorevitalization –

• therapy for biological skin aging,
• photoaging therapy (including hyperpigmentation and rosacea),
• prevention of aging,
• wrinkles, thinning, decreased elasticity, dry skin,
• deterioration of the skin as a result of smoking (including the appearance of small vertical wrinkles on the lips).

Thus, the biorevitalization technique will allow you to improve the color and texture of the skin (especially for smokers), increase its elasticity, reduce the depth of wrinkles, and achieve a skin lifting effect. Additional effects of this procedure may include correction of hyperpigmentation, reduction in the severity of rosacea, as well as inflammatory elements of acne. The severity of a particular effect will directly depend on the composition of the chosen drug.

Differences between biorevitalization and mesotherapy -

Mesotherapy and biorevitalization of the face and neck are very similar procedures and are performed by the same specialists - mesotherapists. So how are they different? When it comes to intensive rejuvenation of the face and neck (using high concentrations of active ingredients), the term “biorevitalization” is used. Mesotherapy uses lower concentrations of active components, and this procedure can be performed not only on the face, but also on the body.

Thus, when it comes to the correction of cellulite or local fat deposits on the body, or procedures are carried out to improve the condition of the hair and scalp, or to improve the condition of the skin of the face and neck (but with low dosages of active substances) - this is called the term “ mesotherapy". If intensive rejuvenation and lifting of the skin of the face/neck is required, then drugs with high concentrations of active substances are used, and in this case the terms “biorevitalization” or “bioreparation” are used.

For example, the concentration of hyaluronic acid (HA) in mesopreparations is usually only from 0.3-0.5%, which corresponds to 3-5 mg/ml, and in biorevitalization products it is usually from 1.5 to 2.0% (= 15-20 mg/ml). Accordingly, in the second case, the saturation of the dermis with moisture will be much more intense, and this will lead to a more noticeable lifting effect. It is also worth noting that low molecular weight HA (with a molecular weight of about 800 kDa) is usually used in mesotherapy, and high molecular weight HA (from 1800 to 3000 kDa) is used in biorevitalization procedures.

An important point is that mesopreparations are made on a water or sol basis (sol is a liquid gel), and biorevitalizants are produced in the form of viscous gels. This greatly affects the time of drug deposition in tissues. Those. if in the first case, the drugs quickly spread in the tissues and are quickly eliminated from them, then in the second case, a drug depot is created in the tissues (at the site of each injection) for a period of approximately 2-3 weeks. That is why it is customary to inject mesopreparations once a week, and biorevitalizants - usually once every 2-3 weeks. Such differences between mesopreparations and biorevitalizants affect not only the frequency, but also the required number of procedures.

Indications and contraindications for biorevitalization of hands with hyaluronic acid

The skin of the hands, unlike the face and body, has its own characteristic features. It is the hands that age the fastest, which is caused by improper and inadequate care, constant mobility of the hands, as well as exposure to adverse factors on the epidermis, for example, household chemicals. Gardeners, doctors, and people in manufacturing have an increased risk of early wrinkles and creases on the skin of the hands.

But the procedure for biorevitalization of hands using fillers is also indicated in cases where:

• You are going on a trip to hot countries, because dehydrated skin will be more susceptible to the negative effects of ultraviolet radiation.
• You have returned from vacation. The skin, even if treated with sunscreen, requires recovery after sun exposure. Biorevitalization of hands with hyaluronic acid will restore hydrobalance, nourish cell membranes with moisture, and also increase the protective properties of the skin.
• Your skin has become loose and visible wrinkles have appeared on your arms.

The Biomed clinic offers clients a procedure for rejuvenating the skin of the hands using the following biorevitalizants: Aquashine, Filogra, JaluPro, Ial System, which have proven their exceptional safety. In this case, a session of introducing fillers into the skin of the hands cannot be carried out if the doctor identifies the following contraindications:

• Allergy to hyaluronic acid, which contains the drugs “Aquashain”, “Firolga”, “Ial System”, “YaluPro”.
• Pregnancy or breastfeeding period.
• ARVI, exacerbation of chronic diseases.
• Oncological and immunodeficiency conditions.
• The presence of inflammatory lesions on the hands.
• Moles, papillomas, nevi in ​​the area of ​​intended administration of Aquashine, Filogra, JaluPro, Ial System.
• Tendency to form keloids.

Biorevitalization with hyaluronic acid: rationale for effectiveness

Age, ultraviolet radiation, smoking and some other factors lead to gradual aging of the skin. All this leads to a gradual decrease in the activity of fibroblasts and the content of hyaluronic acid (HA) in the skin. A decrease in the activity of fibroblasts leads to a decrease in the production of collagen and elastin, which allows the skin to be firm and elastic, and due to a decrease in the level of HA in the skin, its hydration decreases. As a result, the skin becomes drier and thinner, less elastic, and wrinkles appear.

According to the developers of the biorevitalization method, facial skin rejuvenation occurs by stimulating the activity of fibroblasts that produce collagen and elastin. In addition, the skin’s production of its own HA, which allows it to be more hydrated, also depends on the activity of fibroblasts. For example, if at the age of up to 25 years fibroblasts work at 100%, then in people 25-35 years old their number and activity decrease to 75%, and at 35-45 years old - to 50%, and after 50 years or after menopause in at any age - their number and activity are no more than 25% (compared to young people).

Preparations with low molecular weight HA tend to stimulate angiogenesis and fibroblast function, but at the same time they do not moisturize the skin quite well, because Small HA chains are not able to hold many water molecules (24stoma.ru). But high-molecular HA does not stimulate anything, but retains water well, thereby perfectly moisturizing the skin. Biorevitalizants with HA are indicated primarily for patients with finely wrinkled and tired types of aging, but their use in patients with deformational (edematous) type of aging will only lead to increased swelling and gravitational ptosis of soft tissues.

It is worth saying that now mesopreparations and biorevitalizants with hyaluronic acid are used in most cases by specialists thoughtlessly, because It is believed that the larger the HA, the better. But that's not true. The fact is that when carrying out frequent injections with HA, the latter not only stimulates the activity of fibroblasts or increases skin hydration. Frequent use leads to the activation of enzymes: 1) hyaluronidase - an enzyme that destroys endogenous hyaluronic acid produced by fibroblasts, 2) metalloproteinases - enzymes that destroy the intercellular matrix. Therefore, in fact, you should not do injections with HA more than once a month, and it is better to alternate them with other groups of drugs.

The best American drugs for biorevitalization

American biorevitalizants have proven themselves to be highly effective and safe around the world. They are often preferred by masters of the best beauty salons.

Meso-Xanthin F199

Rating: 4.9

The first place in the ranking was given to the drug Meso-Xanthin F199, which is produced by the American company ABG Lab. Along with hyaluronic acid, this biorevitalizant contains a carotenoid - fucoxnathine, regulatory peptides, nucleic acids, essential amino acids, antioxidants and vitamins. Cosmetologists offer Meso-Xanthin to their patients from the age of 25.

Mesoxanthin comprehensively solves both cosmetic and dermatological problems. After biorevitalization, valuable elements necessary for aging skin accumulate in the treated area. It is recommended to undergo 4-5 procedures, taking a break of 3 weeks between each one. The cosmetologist can prescribe a second course after 6 months.

Reviews of Meso-Xanthin F199 often contain information that the result of biorevitalization is much better than initially expected. Noticeable improvements are observed after the first procedure. The skin looks fresher, its tone is evened out, and facial wrinkles become less pronounced. And after a full course of biorevitalization, the skin is transformed to the maximum.

Advantages

• balanced composition;
• after the full course, wrinkles on the forehead are smoothed out;
• facial skin is noticeably tightened;
• the elasticity and tone of the skin improves;
• pigment spots disappear;
• manifestations of rosacea are reduced.

Flaws

• allergic reactions are possible.

Juvederm Hydrate

Rating: 4.7

The biorevitalization drug Juvederm Hydrate from Allergan took second place in the ranking. A biorevitalizant based on hyaluronic acid has a consistency more like a solution than a gel. Juvederm Hydrate is designed to deeply hydrate and give skin a youthful appearance for patients aged 25-35 years.

It was ranked among the best thanks to its composition. The main difference between the drug is the presence of the antioxidant mannitol (9 mg). Thanks to it, Juvederm Hydrate is more stable, and dermal cells become less susceptible to the negative effects of free radicals. Also, due to mannitol, the effect of this biorevitalization drug is prolonged almost 3 times.

Advantages

• contains mannitol;
• deeply moisturizes facial skin;
• returns radiance, elasticity, tone to the skin;
• long lasting effect up to 12 months.

Flaws

• temporary papules, itching, redness immediately after the procedure.

Biorevitalization technique –

There are several injection techniques - nappage, papules, tubercles, as well as the linear-retrograde technique.
If all of them are used in mesotherapy, then when carrying out biorevitalization - everything except the “nappage” technique, which is associated with the inability of this technique to achieve deposition of the drug in the dermis. Before the biorevitalization procedure, superficial anesthesia of the skin is required using gels and creams containing from 5 to 12% of the anesthetic lidocaine. The cream is applied to the face for 15-20 minutes (under the film).

Papules (superficial or medium) –

This technique involves injections into the dermal layer of the skin, in such a way that at the site of each injection a “papule” will form, which looks like an elevation above the surface of the skin (Fig. 5). The size of the papules will depend on the volume of drug removed at each injection point. Papules can be small (micropapules), having a diameter of 1-2 mm, in which case injections are performed into the upper layers of the dermis. Each injection produces a volume of the drug of about 0.01-0.02 ml, the distance between papules is about 0.3 to 0.5 cm. Micropapules are usually made in areas with thin skin, for example, in the periorbital zone.

In areas with dense skin, papules are made of medium size - 3-4 mm in diameter, injecting 0.03-0.04 ml of the drug with each injection. The needle will penetrate into slightly deeper layers of the dermis, and the distance between papules should be about 1.5 cm. It should be noted that the larger the papules, the slower they will resolve. Usually papules disappear within 3 days, and in rare cases – up to 5-7 days. But if the doctor made medium-sized papules using a drug with partially stabilized hyaluronic acid (doctor’s mistake), then we can sympathize with you, because they will dissolve in about 3 weeks.

Superficial papules: video

Technique “tubercles” –

This technique has a big advantage, because... after it, the skin at the injection sites is practically invisible, and only traces of needle injections are visible. If with the “papules” technique injections are made with a needle placed at an angle of 15 degrees to the surface of the skin, and thus a drug depot is created in the upper or middle layers of the dermis, then with the “tubercles” technique - injections are made with a 4 mm needle at 45 degrees in the skin surface . Thus, the drug depot is created in the deeper layers of the dermis (at a depth of about 3 mm).

The distance between injections is 1.0 on the face, on the neck it is usually 1.5 cm. The disadvantage of this technique is that it is more difficult to control the volume of drug removal at each point.

Linear-retrograde technique –

This technique came from contouring, and most mesotherapists do not like it, because... technically it is the most difficult. However, it is also the most effective, and the same technique is also used for bioreinforcement of the face. If for previous techniques 4 mm needles are used, here they are 12-13 mm long. After injection, the needle is given a horizontal position, and it advances in the middle layers of the dermis parallel to the surface of the skin for its entire length. The drug is administered by retrograde movement of the needle backwards.

This technique is successfully used in the middle and lower thirds of the face - in the area of ​​the cheekbones, cheeks, chin, corners of the mouth, facial contours (strictly along massage lines), in the neck area, and also around the eyes. It allows you to reduce the number of needle injections several times, thereby reducing the rehabilitation period. Advancing the needle 13 mm into the dermis leads to more pronounced subdermal damage (than when using 4 mm needles), which means tissue regeneration will be more active. This means that collagen synthesis will increase not only due to the introduction of active substances, but also in response to damage.

Linear-retrograde technique: video

Important: the biorevitalization procedure itself will take about 15-20 minutes. After the procedure, the skin is treated with a chlorhexidine solution. However, the indicated time does not take into account the lymphatic drainage vascular injection of the face and collar area, as well as the 15-20 minutes required to apply a special mask to the face, which will help minimize the visibility of needle injection marks and relieve redness.

The best Asian preparations for biorevitalization

Korean biorevitalizants are popular among cosmetologists due to their rich composition and long-lasting effect after the procedure. The line of each brand is represented by several products, varying in the concentration of hyaluronic acid and a number of other characteristics.

Mesoheal +

Rating: 4.9

The first place in the ranking is occupied by the drug Mesoheal + from the Korean company Koru Pharmaceuticals. This biorevitalization filler contains 25 mg of unstabilized hyaluronic acid in each syringe. The drug is injected into the superficial layers of the dermis. A distance of 1 cm is maintained between adjacent injections.

The drug can be administered papularly, multipuncture or using a linear-retrograde technique. Mesoheal+ can be used on the face, neck, décolleté, and other areas of the body. In order to achieve maximum results, cosmetologists recommend doing 4-6 procedures with an interval of 10-14 days.

There are mostly positive reviews about this drug. Biorevitalizant allows you to quickly and maximally moisturize the skin and restore its elasticity due to the production of natural collagen and elastin. This product is deservedly in first place in the ranking, since it provides facial lifting and regulates melanogenesis better than others.

Advantages

• significantly transforms aging skin;
• relieves inflammatory processes;
• normalizes the functioning of the sebaceous glands;
• smoothes expression wrinkles;
• improves the appearance of hyperpigmented areas.

Flaws

• Papules on the neck and décolleté take longer than a week to resolve.

Aquashine

Rating: 4.8

The second place in the rating is given to the drug Aquashine from the South Korean concern Caregen. It has an interesting mechanism of action. Along with hyaluronic acid 1.5%, the product contains stimulating and inhibitory peptides. Stimulants activate the production of natural lycoproteins, proteoglycans and hyaluronic acid. Inhibitors inhibit the destruction of extracellular matrix components.

A biorevitalization course with Aquashine consists of 3-4 sessions. Between each one take a break of 3-4 weeks. A different number of procedures is selected for each patient. In reviews, women note that after just one manipulation their complexion improves, their skin becomes more elastic and toned, fine wrinkles are smoothed out, ptosis is reduced, and sebum returns to normal.

Advantages

• rich composition;
• eliminates signs of dehydration;
• tightens pores;
• fights fine wrinkles;
• normalizes melanin synthesis;
• slows down the aging process.

Flaws

• papules and bruises from injections for 5-7 days.

Yvoire Hydro

Rating: 4.7

In third place in the ranking was the drug Yvoire Hydro, which is produced by the South Korean company LG Life Sciences. This biorevitalizant contains 2% hyaluronic acid and phosphate buffer. HA is obtained by microbiological fermentation. It is completely compatible with the tissues of the human body and does not cause rejection.

It has good spreadability and uniform distribution after administration. The technique of administering the drug is different: linear (filling superficial wrinkles), “mesh” (strengthening problem areas), papular or short-linear. In all cases, injections during biorevitalization are made close to the surface of the skin.

Cosmetologists and their clients note in their reviews that this drug effectively eliminates dryness and sagging skin of the face and body. It also visibly corrects fine superficial wrinkles and promotes overall skin health. And some also claim that the effect of the procedures lasted for 1.5 years.

Advantages

• launches skin rejuvenation processes;
• the drug is highly stable and provides a long-lasting effect;
• effectively combats dryness;
• eliminates various imperfections of the skin.

Flaws

• After the procedure, swelling, skin soreness, and bruising appear.

Important: selection of drugs for biorevitalization

In practice, we most often encounter 2 types of skin aging. Firstly, a finely wrinkled type of aging, which appears already by the age of 30, and in the eye area even earlier. This type is characterized by thin, dehydrated skin and a large number of small expression wrinkles, especially in the eye area. For this type of aging, the use of hyaluronic acid (HA) is a priority. And if in young patients 25-30 years old it is still possible to use biorevitalizants containing only HA, then in patients 30-35 years old the biorevitalizant must already contain vitamins, microminerals, amino acids, and antioxidants.

In patients aged 35-40+ years with a fine wrinkled type, the biorevitalizant should preferably contain (in addition to the above components) nucleotides and matrikin peptides. The latter stimulate collagen synthesis. Moreover, after 30-35 years with this type of aging, in order to achieve a good effect, it is desirable to carry out in parallel 2-3 procedures of capillary mesotherapy of the face, neck, collar area with vascular / drainage drugs - to stimulate lymphatic drainage and blood supply to the skin.

But if patients of this type show symptoms of skin photoaging - such as hyperpigmentation and telangiectasia, then additionally vitamin C, antioxidants (glutathione, coenzyme Q10, thioctic acid), cysteine, lightening peptides will be needed. Vitamin C and antioxidants relieve oxidative stress that occurs when exposed to solar radiation. A drug with this composition will also be useful before going on vacation to hot countries.

Deformation type of aging - but the main type of aging of most Russian women is deformation (edematous). Such patients usually have dense skin, fairly few wrinkles, a large volume of soft tissues of the face due to interstitial edema of the subcutaneous fat, and also have pronounced nasolabial folds and jowls. This type of aging develops due to impaired venous outflow in the face and neck, and is provoked primarily by problems with the cervical spine. If such patients are given drugs with GC, this will further increase the swelling of the face and, as a result, gravitational ptosis of the soft tissues.

Therefore, in such patients, capillary mesotherapy (lymphatic drainage vascular injection) takes first place, as well as, according to indications, the use of lipolytics in the area of ​​fat pads of the face and double chin. During the first 2-3 visits, capillary mesotherapy can be carried out as a single procedure, or it can be combined immediately with the introduction of biorevitalizants. The latter, in case of deformation/edema type of aging, should contain DNA-RNA complexes, as well as vitamins (primarily vitamin C), amino acids, and peptides.

Why is “capillary mesotherapy” (vascular injection) needed?

It is impossible to achieve a pronounced biorevitalization effect (primarily with the deformation type of aging) without stimulating the blood supply to the skin and activating lymphatic drainage. This injection is carried out with vascular preparations “Artichoke”, “Gingko Biloba”, “Rutin + melito extract” or “GAG Complex DVL Capyl”. This is especially true for patients with ptosis, rosacea or complaints of facial swelling. In all these groups of patients, lymphatic drainage vascular injection of the face and cervical-collar area should be done at least 4-5 times.

The volume of vascular preparations per procedure should be no more than 5 ml. First, the cervical-collar area is treated, then injections are made in the projection of the lymph nodes - the area of ​​the earlobes, the sternocleidomastoid muscle, in the area of ​​the jugular fossa and clavicles, as well as in the submandibular area. After this, a series of injections are made along the massage lines of the face and the infraorbital area. In patients with a finely wrinkled type of aging, it is advisable to do 1-2 such vascular puncture procedures, but in patients with a deformational type of aging or patients over 45 years old, 5 or more procedures can be safely performed.

The combination of the drainage drug “Artichoke” with the vascular drug “Rutin + melito extract” will normalize venous outflow, activate lymphatic drainage and microcirculation. All this will remove interstitial edema of the subcutaneous fat, which will reduce the volume of soft tissues and the degree of gravitational ptosis, as well as the severity of the folds. If a patient is prescribed a course of several biorevitalization procedures, then each procedure begins first with a vascular puncture and only after that are injections of the biorevitalizant given. Or the first 2-3 procedures are done only by capillary mesotherapy + soft lipolytics on the face, and biorevitalizants are added only from the 4th procedure.

Cosmetologist’s opinion: “Russian preparations for biorevitalization are absolutely competitive”

Russian women have always been famous for their beauty and grooming. For this, our grandmothers and mothers had to rely on folk recipes and a limited selection of industrial creams. We are luckier: we have a huge range of high-quality cosmetics and beauty treatments at our disposal.

Bioreparation, a more advanced version of biorevitalization, is considered one of the most effective methods of skin rejuvenation all over the world. In our country, well-proven Russian drugs are increasingly used for this purpose. On Beauty Day, which is celebrated all over the world on September 9, PharmMedProm asked Yulia Alekseevna Rodina , PhD, dermatovenerologist, cosmetologist, trichologist at the Institute of Plastic Surgery, and cosmetology, a member of the National Society of Mesotherapists, a member of the Union of Trichologists and a certified trainer in injection methods.

What problems does biorevitalization help solve?

The main effect of revitalization is very good hydration. A more innovative version of this procedure is bioreparation, which gives an enhanced effect. In addition to moisturizing the skin, it stimulates active collagen synthesis and cell regeneration. As a result, we achieve improved skin quality, fine wrinkles are smoothed out, puffiness is removed, the skin is brightened and tightened, and its elasticity increases.

Both procedures are approved for use from the age of 18 onwards without restrictions. In patients aged 18-25 years, biorevitalization and bioreparation are used mainly to prevent aging through hydration, but they can also help solve some other problems. For example, to eliminate scars or stagnant pigmentation after acne or relieve the patient from excessive dry skin. In older people, procedures are most often used as anti-aging therapy, allowing not only to well moisturize the skin and lighten certain areas of the skin (for example, elbows, knees or armpits), but also to achieve a lifting effect and eliminate fine wrinkles and age spots, as well as hyperpigmentation resulting from excessive sunbathing without sunscreen. There is no upper age limit for bioreparation and biorevitalization: if 75-year-old patients come to us with a desire to improve the quality of their skin, we work with them and achieve a fairly good result.

Biorevitalization and bioreparation are used in the face, neck, décolleté, hands, abdomen, elbows and knees, in short, on almost any area of ​​the skin.

Biorevitalization can improve skin quality on almost any area of ​​the skin

Are biorevitalization and bioreparation popular in other countries of the world or are we lagging behind in this matter?

Both procedures are very popular all over the world, not only in Russia. If the drug and course are chosen correctly, the result will be clearly visible. The procedure is quite comfortable and well tolerated by patients; if necessary, anesthesia can be applied first. The only thing worth paying attention to is the short rehabilitation period and the presence of small and quickly passing single bruises.

For reference: specialists who offer skin care in beauty salons are called estheticians. They, as a rule, have secondary vocational education, so they do not have the right to prescribe and perform procedures that violate the skin, including “beauty injections.” This requires a higher medical education as a dermatovenerologist and additional specialization in cosmetology. Accordingly, injection procedures, for example, biorevitalization or bioreparation, are performed by dermatovenerologists and cosmetologists.

Russian cosmetologists and manufacturers work closely with foreign colleagues, participate in international conferences, so in the field of cosmetology we not only keep up with specialists from the rest of the world, but also surpass them in some issues. I mean, for example, the development of drugs such as the Russian brand REVI, which has a completely unique composition and effectiveness.

Tell us more about the Russian preparations for biorevitalization and bioreparation that you use in your work.

There are several dozen drugs on the market for these procedures, but in order to use any injectable drug, you must undergo special training and obtain a certificate. By learning to work with the drug to achieve maximum results, the doctor learns how to administer it correctly, what indications the drug has and what course the patient needs to take to get a good result. It is clear that it is impossible to work with all drugs at once and know them well, so a cosmetologist’s portfolio usually contains about 5-7, maximum 10 drugs for different indications and different price categories. Periodically, with the advent of new products, this portfolio is updated. In mine, for example, there are three Russian brands: REVI (REVI) and Bellarti (Bellarti) for bioreparation and HYALUFORM (HYALUFORM) for biorevitalization.

REVI brand has been present on the Russian market for more than 11 years; several years ago the manufacturer rebranded the products, but they remain one of the most popular and effective products for bioreparation. Their peculiarity is that they consist of only two components - hyaluronic acid and trehalose (healthy sugar of natural origin), but this combination gives a much better result and solves more problems than multicomponent foreign analogs consisting of 40-50 ingredients. The danger of such multicomponent drugs is that it is difficult to predict how these components will work in combination with each other and how the body will perceive them, so the whole world is trying to switch to monocomponent products such as REVI, in which hyaluronic acid is supplemented with only one ingredient. At the same time, REVI drugs have a number of advantages, a convenient course and frequency of administration, as well as a long-lasting effect, since they are considered prolonged revitalizants, that is, their effect lasts longer than that of conventional drugs. The unique composition and long-lasting effect make this brand one of the most popular in Russia. REVI belongs to the top price category, but the result is worth it.

Another Russian brand I work with is called Bellarti . This is new, but it has its advantages. In addition to hyaluronic acid, Bellarti products contain a strong antioxidant that protects the skin from oxidative stress (damage to skin cells due to oxidation). In poor environmental conditions, the skin of residents of megacities is exposed to the harmful effects of free radicals, and Bellarti products effectively combat the consequences of this exposure. Bellarti belongs to the middle price category.

As for the HYALUFORM , which has also existed on the Russian market for about 20 years and has also recently undergone rebranding, these are monopreparations consisting of high-quality hyaluronic acid of pharmacopoeial class, and therefore used for biorevitalization. In the manufacture of HYALUFORM preparations, PMMP technology is used, which ensures uniform distribution of drugs in the dermis and provides a longer revitalizing effect. Prices for HYALUFORM are quite affordable, and the effect is clearly visible.

Before and after biorepatation - photos from the personal archive of dermatovenerologist and cosmetologist Yulia Rodina

Before and after biorepatation - photos from the personal archive of dermatovenerologist and cosmetologist Yulia Rodina

Before and after biorepatation - photos from the personal archive of dermatovenerologist and cosmetologist Yulia Rodina

What are the advantages of Russian drugs for biorevitalization and bioreparation?

I believe that these Russian drugs are absolutely competitive in terms of duration of action and tolerability, and, most importantly, in terms of their effect and are in no way inferior to imported drugs. At the same time, REVI is distinguished by a truly innovative composition, and Bellarti and HYALUFORM, with competitive quality and high efficiency, are more attractive in terms of cost compared to foreign analogues. All of them have passed the necessary clinical studies, received official certification as third-class medical devices, registered and approved for use in Russia.

How to check the authenticity of drugs in a cosmetology salon?

By learning to use this or that drug, and then purchasing it for his practice, the dermatovenereologist-cosmetologist receives not only a certificate of his own training, but also a certificate of registration of the drug in Russia. The patient has the right to ask to see them and thus be convinced of the authenticity and quality of the drug.

How do you choose which drug to offer a patient – ​​Russian or foreign?

I rely only on the testimony that the patient has. Before the procedure, the doctor finds out about the presence of chronic and other diseases in the patient, clarifies what medications he is taking, and then evaluates the condition of the skin. Based on this data, as well as the patient’s wishes regarding the price category, a decision is made which drug is best suited in this particular case.

How do your patients react when they find out that the products are Russian?

About two years ago, our patients treated Russian drugs with great caution. Now the situation has changed. Before use, I tell you in detail about the drug - its composition, manufacturer, properties, course of use and explain why I offer it. People are no longer afraid that the Russian drug may be of poor quality or not produce results. Word of mouth works well for patients and they quickly become aware of such quality products and services. Honest “before and after” photos that doctors and patients post on social networks also help.

Please tell me, Yulia, do you try products on yourself when choosing them for work?

Before we start using the drug, we undergo training and use only what we consider to be a good and effective remedy. Of course, a lot depends on the properties of the drug and the duration of the course, but if the product suits me and I trust its quality, I try it on myself, and if I see the result, I begin to actively work with it and recommend it to patients. It is very important to me that the drugs I use in my work are not only effective, but also safe, well tolerated by patients and have no side effects.

I have tried both Russian and foreign drugs on myself, so I can evaluate not only the effectiveness and good tolerability of Russian drugs, but also make them the drugs of choice for my patients.

Interviewed by Alexandra Komarova

“Before and After” photos: from the personal archive of Yulia Rodina

Photo: iStock by Getty Images

Post Views: 796

How to choose a drug for biorevitalization -

Preparations for biorevitalization are currently produced by countless companies.
One of the main components for these purposes are hyaluronic acid (HA) molecules. Typically, the lifespan of chemically unmodified (unstabilized) HA molecules is only 24 to 48 hours. However, biorevitalizants are produced in the form of a viscous gel, which allows even unstabilized HA to be deposited for a slightly longer period, reducing the rate of its destruction. The properties of the drug are very dependent on the molecular weight of the HA chains. High molecular weight HA (from 1500 to 3300 kDa) moisturizes the skin well, but does not have a stimulating effect on fibroblasts. Low molecular weight HA has a stimulating effect on fibroblasts and angiogenesis, but rather weakly moisturizes tissues. At the same time, low-molecular HA is destroyed faster in the skin than high-molecular HA (unless, of course, it has been chemically modified). For example, the preparation “Ial-system ACP” contains stabilized low-molecular HA with a molecular size of 200 kDa.

According to the manufacturer, the degradation period of HA in this drug is 10 days, and given the size of the molecules, one can immediately understand that the drug mainly has a stimulating effect on fibroblasts, activating collagen synthesis in them, but the moisturizing effect of such a drug will be less pronounced than if we will use a drug with high molecular weight HA with a molecular size of, for example, 1800 kDa or more. Next we look at the percentage of HA content in the drug. For drugs with unstabilized HA, its optimal concentration is 1.8-2.0%, but if we are talking about drugs with stabilized HA, then 1.4% is enough.

Important: modern data suggests that preparations with hyaluronic acid should not be used more than once a month, because frequent administration of high concentrations of HA leads to - 1) increased production of the enzyme hyaluronidase, which accelerates the destruction of its own HA synthesized by fibroblasts, 2) enhances the activity of metalloprotease enzymes that destroy the intercellular matrix. Those. it turns out that you inject too much HA into the dermis, and the body reacts to this with a surge in the production of hyaluronidase, which will rapidly destroy not only the biosynthetic HA you introduce, but also its own endogenous HA produced by fibroblasts.

Therefore, it is worth using biorevitalizants with HA no more than once a month, alternating them, for example, with nucleotides. Or another option is to use biorevitalizants with stabilized HA, which has the property of gradually releasing chains of active hyaluronic acid without creating excessively high concentrations of active HA molecules in the tissues over a short period of time. Such drugs act gradually and over a longer period of time, and are usually administered once every 3-4 weeks. Examples of drugs are “Restylane Vital”, “Juvederm Hydrate”, “HyalRepair”, etc.

Mono-preparations with hyaluronic acid –

Below we give an example of the most famous monopreparations with hyaluronic acid. Please note that in any case it makes sense to take such drugs only up to 30-35 years of age. After this age, it is impossible to achieve good skin lifting or intensive rejuvenation using HA alone. More or less the effect will be noticeable only after a course of 4-5 procedures, and then only if your skin is in relatively poor condition. These drugs will not be particularly effective in case of photoaging, because These do not contain a complex of components to relieve oxidative stress.

• Restylane Vital and Restylane Vital Light (Sweden) are the first biorevitalizants in which the technology of chemical modification of HA (i.e., its stabilization) was applied. The preparations contain only 2% and 1.2% hyaluronic acid, respectively, and are used in patients with finely wrinkled type of facial aging: Restylane Vital - for more mature skin, and Restylane Vital Light - to prevent aging of younger skin. Reviews: these drugs are of high quality, but their composition is outdated, and they are suitable for no more than the prevention of age-related changes, and then only with a stretch.

• Juvederm Hydrate (USA) – contains 1.35% stabilized hyaluronic acid + antioxidant mannitol. The antioxidant is quite weak, so the drug is not very suitable for the treatment and prevention of photoaging. Reviews: in our opinion, Juvederm Hydrate should be used only for the prevention of aging in patients with fine wrinkles, and no older than 30 years. A course of at least 3-4 procedures performed once every 3 weeks will be more or less effective.
• The drugs “Ial-system” and “Ial-system ACP” are a line of two biorevitalizants produced in Italy. The drug "Ial-system" contains 1.8% of unstabilized low molecular weight hyaluronic acid (molecule size only 200 kDa). Accordingly, its effect occurs quickly, but will not be too long-lasting, and besides, such a drug moisturizes the skin less - compared to drugs based on high molecular weight HA. Available in 0.6 or 1.1 ml syringes.
  The second drug is “Ial-system ACP”. Available in 1.0 ml syringes and containing 2% partially stabilized low molecular weight HA (molecule size also 200 kDa). According to the manufacturer's information, HA remains in the skin a little longer - about 10 days, but this, of course, is still significantly less than the above-mentioned drugs from other brands. Reviews: in our opinion, Ial system biorevitalization is optimal only for the prevention of aging in patients no older than 35 years.

Combined preparations with HA (cocktails) –

The group of these drugs is so numerous that we will present only one of the many options - the Revofil Aquashine line of affordable drugs (made in Korea). Available in 2.0 ml syringes.

• Biorevitalizants Revofil Aquashine - the first option is “Aquashine”, containing unstabilized high molecular weight 1.5% HA, peptides, amino acids, vitamins and minerals, coenzymes (56 components in total).
  In our opinion, it is better to use in patients 35+; it gives a good lifting effect when used as a course. The second option is “Aquashine BR”, which additionally adds peptides that lighten the skin, and therefore it is well suited for hyperpigmentation, for example, for aged skin 45+, as well as for the treatment and prevention of photoaging. “Aquashine BTX” – suitable for ages 30+. It also has a similar composition, but peptides are additionally added to it, the effect of which is similar to Botox®, i.e. smooth out small facial wrinkles. Aquashine biorevitalization reviews: these drugs are suitable for patients with moderate age-related changes. Not suitable for patients with deformational/edema type of aging.

Powerful biorevitalizants for aging skin –

If your age is 40-45+ and you need a noticeable lifting effect and reduction in the depth of wrinkles, then hyaluronic acid, vitamins, minerals, amino acids and antioxidants alone are no longer enough. This requires nucleotides (DNA-RNA complexes), as well as peptides and growth factors. At this and even more so at an even more mature age, the dermis contains a significantly smaller number of fibroblasts, not to mention their activity. And if there are almost no fibroblasts, then there is nothing to stimulate. This is especially true for postmenopausal women.

• Nucleotide-based drugs – an example is NucleoSpire DNA-RNA from Mesopharm®. It contains nucleotides in a concentration of 2% and is available in syringes of 1.3 and 2.0 ml. Reviews: the drug gives a delayed but pronounced lifting effect, stimulates collagen production, and is used to correct hyperpigmentation, chrono- and photoaging. Suitable for intensive rejuvenation, can be used periodically in patients 35+ and regularly after 40-45 years. Suitable also for patients with deformational (edematous) type of skin aging. A similar drug based on nucleotides is Plinest (Italy). These drugs do not work for young people.

• “Meso-Wharton P199” - this drug contains not only nucleotides, vitamins (A, E, C, group B), trace elements and antioxidants, but also high molecular weight 1.5% hyaluronic acid (with a molecular size of 3300 kDa). This drug contains growth factors, as well as peptides that stimulate the proliferation of fibroblasts and stem cells in the dermis, and also enhance the production of new collagen by fibroblasts. Not for deformation/edema type of aging.

• The “HYALREPAIR” line – biorevitalizant “Hyalrepair -02” contains 1.4% stabilized HA, vitamin C and the main amino acids involved in collagen synthesis, these are proline, glycine and lysine. An excellent product for loose, finely wrinkled skin. The drug “Hyalrepair -04” - in addition to the same hyaluronic acid, contains vitamin C, glutathione and cysteine. This drug is well suited for the treatment of photoaging, copes well with the network of fine wrinkles, hyperpigmentation and rosacea. The course of these drugs usually consists of 3 procedures at intervals of 3 weeks.

• “Nucleospire Revitalizing Complex A” is a good biorevitalizant based on 1.8% unstabilized HA, with a large amount of antioxidants (vitamin C, glutathione, thioctic acid, coenzyme Q10), vitamin B5. This composition perfectly relieves oxidative stress after sun exposure, helps moisturize the skin, lighten hyperpigmentation and prevent its formation. Those. this drug is good for photoaging, optimal before and after vacation to hot countries. You can have 30+ regularly (and even 25+, but not often).

• 
  “Nucleospire Revitalizing Complex B” (Hydro Line Extra) is a good biorevitalizant also based on 1.8% unstabilized HA, contains 19 amino acids, all B vitamins, microminerals, and the antioxidant glutathione. If the previous drug is used for the prevention and treatment of photoaging (including at a moderately young age), then this drug is for aging skin and is intended to stimulate collagen production. Naturally, it is not as effective as Meso-Wharton P199, but it also costs 2 times less.

Important : for aging skin, only a course of biorevitalization (from 3 to 7 procedures) can give a good effect. Most often, the course is carried out not with one particular drug, but with a combination of several, and their choice for each woman will be individual.

The best European drugs for biorevitalization

Cosmetologists work with Italian, Swiss, French, German, Austrian and Russian biorevitalizants. Some specialists have their own personal preferences, but when choosing a specific brand, they take into account the age of their patients and changes in their skin.

Teosyal Meso Expert

Rating: 4.9

The first place in the ranking is occupied by the drug Teosyal Meso Expert, created by the Swiss laboratory Teoxane. It contains non-reticular hyaluronic acid (15 mg/ml). It also includes a full complex of other components (amino acids, peptides, vitamins) useful for skin restoration.

The drug relieves inflammation, fights free radicals, reduces the damaging effects of sunlight, restores skin, and stimulates metabolic processes. With its help, injections are made intradermally, linearly or papularly. Teosyal Meso Expert is suitable for the age category from 25 years.

Advantages

• the concentration of active substances is adapted to any skin type;
• deeply nourishes, moisturizes;
• eliminates facial wrinkles and folds of the nasolabial triangle;
• eliminates bags under the eyes;
• fights hyperpigmentation;
• triggers the synthesis of collagen and elastin.

Flaws

• every 2-3 months you need to maintain the effect obtained.

IAL-system

Rating: 4.8

In second place in the ranking are biorevitalizants IAL-system (Ial System), produced by the Italian pharmaceutical company Fidia Farmaceutical. The products comply with the international standard ISO 9002. Biorevitalization preparations from this brand are sterile, viscous gels.

IAL-system contains unstabilized hyaluronic acid (18 mg/ml) and sodium chloride. Biorevitalization with this product is indicated for patients with dry and atopy-prone skin. Papular administration is carried out into the superficial layers of the epidermis. Course: 3-5 sessions with frequency - 1 time in 2-4 weeks.

Advantages

• suitable for any skin, especially dry and thin skin;
• universal, safe;
• high level of hydration;
• smoothes out small wrinkles;
• significantly improves complexion.

Flaws

• after the procedures, puncture sites take longer to heal than after other means;
• a hematoma may appear at the injection site (resolves within 4 days).

Filorga M-NA10

Rating: 4.7

Third place in the ranking was given to the leading French manufacturer of anti-aging drugs for biorevitalization - Filorga. These cosmetics may contain 10 or 18 mg/ml hyaluronic acid (M-HA10/M-HA18). Filorga M-HA10 is the “lightest” option for young skin (27-29 years old).

The drug is indicated for dull complexion and dehydrated skin. It is used for recovery after tanning, peeling or plastic surgery, and also as a means to prevent age-related changes. The course consists of 2 procedures with an interval of 3 weeks.

Girls in their reviews note that with the help of this product they were able to get rid of post-acne and scars, their complexion evened out and a healthy glow appeared. But if the skin is severely dehydrated, and the areas around the eyes are also problematic, then they recommend choosing Filorga M-HA18.

Advantages

• stimulates natural collagen production;
• effectively moisturizes the dermis;
• after the procedure, the skin is restored in 1-3 days;
• Suitable for early use from 27 years of age.

Flaws

• After the procedure, hematomas and redness are possible (they go away on their own).

Princess Rich

Rating: 4.6

Fourth place in the ranking went to the biorevitalization drug Princess Rich from the Austrian company Croma. Along with hyaluronic acid, it contains glycerol molecules. Used for biorevitalization procedures of the face, neck or décolleté. The drug is injected into the superficial layers of the dermis.

Princess Rich meets all international standards and has been successfully used by leading cosmetologists since 2009. This product was included in the rating of the best due to its composition. The combination of glycerin and hyaluronic acid not only increases the moisturizing effect of the drug, but also the results last longer.

Princess Rich restores the water balance of the skin and stimulates the natural renewal of the extracellular matrix. In their reviews, cosmetologists note that thanks to this drug, their patients have a healthy color and radiance of the skin. After a series of manipulations with this biorevitalizant, the number of wrinkles is noticeably reduced, the skin becomes toned and well moisturized.

Advantages

• composition (hyaluronate combined with glycerin);
• increases skin turgor;
• corrects the structure and contour of the face;
• eliminates bags under the eyes;
• does not cause allergic reactions.

Flaws

• the first effect is noticeable 7-10 days after the procedure.

Biofactor

Rating: 4.5

Fifth place in the ranking of the best drugs is taken by the German Biofactor. The biorevitalization product is available in two forms: 2% and 3.5%. The first one saves from dryness and decreased skin elasticity. The second not only intensively moisturizes, but also eliminates drooping of the upper eyelid (ptosis) and wrinkles. Biofactor products are suitable for working with any area of ​​the face or body. The drug is administered papularly.

The advantage of this biorevitalization product is its high safety. Its components are not of animal origin. The composition of artificial hyaluronic acid is as close as possible to the biological one produced by the body. Its main task is to restore water balance and also improve the production of fibroblasts.

To achieve maximum results, biorevitalization with this drug is not done once, but periodically. The full course consists of 4-6 sessions. Between them they take a break of 1-4 weeks. In reviews, women note that the resulting effect lasts up to six months on average. But a lot depends on age and subsequent care.

Advantages

• hypoallergenic composition;
• increases skin elasticity;
• has a slight lifting effect;
• reduces the depth of wrinkles;
• improves the general condition of the skin.

Flaws

• Not very effective for mature skin with severe problems.

Repleri

Rating: 4.5

The ranking of the best European drugs for biorevitalization is completed by Repleri. It was developed by the Russian company NovoNexus. Contains stabilized hyaluronic acid of non-animal origin. This biorevitalizant is universal and suitable for various types of age-related changes on the face.

The Repleri line includes 6 products with different molecular weights of hyaluronic acid. Each of them fills and smoothes wrinkles taking into account individual characteristics. After some time, the injected hyaluronic acid completely disintegrates. Cosmetologists believe that this product deserves to be in the ranking of the best, since it has passed numerous tests in leading medical institutes of the Russian Federation.

To achieve maximum effect, 3-5 biorevitalization sessions are performed with an interval of 2 weeks. In their reviews, women note that the condition of the tissue remains improved even after the drug is completely removed from the body. Facial skin continues to look younger and fresher.

Advantages

• lasting results up to 12 months;
• when used correctly it is absolutely safe;
• effective against fine expression wrinkles.

Flaws

• If the administration technique is not followed, necrosis, thrombosis, and fibrosis may develop.

Biorevitalization: price for 1 procedure

How much biorevitalization of the face and neck costs will depend on the cost of the chosen drug, as well as the amount of the clinic’s markup. In most clinics the markup is +150-200% of the cost of the drug. Private cosmetologists usually have a markup of +100%. For the biorevitalization technique, the cost of 1 procedure in mid-price clinics will be (for 2022) –

The purchase price for cosmetology clinics for Restylane Vital and Vital Light is about 5,000 rubles (for 1.0 ml), for Juvederm Hydrate – 4,000 rubles (for 1.0 ml), for Aquashine – about 3,500 rubles (for 2.0 ml) etc. But you must understand that the cost of the service includes anesthesia, consumables, and the cost of a special regenerating mask, which must be applied to the face after the procedure. Don’t forget about office rent, employee salaries, taxes, reimbursement of specialist training costs, etc.

→ Cost of facial mesotherapy procedures → Cost of hair mesotherapy

Rating of the best drugs for biorevitalization

Facial biorevitalization: before and after photos, effect

You will have great difficulty finding real photos before and after biorevitalization, because... Cosmetology clinics post only cases of the most successful procedures, or simply take photographs of patients after hardware rejuvenation techniques, passing them off as biorevitalization procedures. The following 2 photos are from an independent clinical study. Each patient was administered 2.0 ml of Restylane Vital during 1 procedure. The course of treatment consisted of three procedures done with an interval of 4 weeks.

Biorevitalization: before and after photos (course with HA mono-drug)

As you can see: the effect of therapy with a mono-drug of hyaluronic acid in patients aged 35 and 46 years is either minimal or not noticeable at all. As we said above, patients over 30 years old need other drugs containing vitamins, amino acids, microminerals, antioxidants, and 40-45+ also nucleotides, peptides and growth factors. What do you think: will patient reviews for such facial biorevitalization be positive? It is unlikely that cosmetology clinics will post such photographs.

Example No. 2 –

The following photos were taken by cosmetologist Victoria Petrovskaya. The patient underwent a course of 4 procedures, once every 2 weeks. At the beginning of each procedure, lymphatic drainage vascular injection was first performed with the drug “GAG Complex DVL Capyl formula”, then “Hydro Line P-Anti-wrinkles formula” - for the periorbital area, and “Hydro Line Peptide formula” - for all other areas of the face. Photos were taken after the second procedure. Those. Each procedure used the same 3-drug regimen.

Example No. 3 –

The following photos were taken by cosmetologist A.Yu. Voropaeva. The patient underwent a course of 4 procedures, once every 10-14 days. At the beginning of each procedure, lymphatic drainage vascular injection was first performed with the drug “GAG Complex DVL Capyl formula”. Then, different biorevitalizants were used in each procedure -

1. 
   "Nucleospire Revitalizing Complex A"

2. "Nucleospire DNA-RNA 2%",
3. "Nucleospire Revitalizing Complex A"
4. "Nucleospire DNA-RNA 2%".

Example No. 4 –

The following photos were taken by cosmetologist Irina Pyagai. The patient underwent a course of 8 procedures, once every 10 days. At the beginning of each procedure, lymphatic drainage vascular injection was first performed with the drug “GAG Complex DVL Capyl formula”. Different biorevitalizants were used in different procedures -

1. 
   "Nucleospire Revitalizing Complex A"

2. "Nucleospire Revitalizing Complex B formula",
3. "Nucleospire DNA-RNA 2%",
4. "Nucleospire Revitalizing Complex B formula",
5. "Nucleospire DNA-RNA 2%",
6. 7. 8. procedures – “Nucleospire DNA-RNA 1% DM Peptide formula”.

Which brand of biorevitalization drug is better to choose?

Due to the great demand for biorevitalizants, these cosmetic products are produced by many brands, young but promising companies. Only specialists and experienced buyers know how to make the right choice and which brand to give preference to. Experts analyzed offers on the global market and then named the top companies:

• Fidia Farmaceutici SpA (Ial System) is an Italian company that was founded in 1948. It is a leader in the production of hyaluronic acid, with over 40 years of experience. It is a recognized global brand that is the only one with an International patent.
• Caregen LTD (Aquashine) is a South Korean brand that, over almost 20 years of its existence, has been able to take a leading position in the production of biomimetic peptides and growth factors. They are actively used in cosmeceuticals and pharmaceuticals in different countries.
• Teoxane (Teosyal Meso Expert) is a French laboratory that was founded in Geneva in 2003. Engaged in the development of dermal fillers for rejuvenation and healing of the epidermis. Products are distributed to more than 90 countries. In terms of quality and sales volume, it is one of the three world leaders.
• Apharm (Hyamira) is an Italian manufacturer of products for dermatocosmetics, nutraceuticals, and medicine. The laboratory became famous thanks to its innovative development - the viscoelastic solution Hyamira.
• NMTC International (Revi) is one of the largest domestic companies in the aesthetic medicine market. Founded in 2006. It has its own production site and enters into contracts with leading leaders in this industry.
• IBSA Farmaceutici Italia SRL (Viscoderm) is an Italian subsidiary of the IBSA Group corporation, which specializes in the field of pharmaceuticals, medicine, and food supplements. Products began arriving on the Russian market in 2008. All drugs comply with international quality standards. Anti-aging products are especially in demand in Europe and the USA.
• Croma Pharma (Princess Rich) is a pharmaceutical company that was founded in Vienna in 1976. At first she was engaged in the distribution of medicinal products in Austria, and now she has achieved heights in the field of synthetic biomaterials. Products are supplied to more than 100 countries around the world. Over 35 years of operation, the company has taken a leading position in Europe in the creation of viscoelastic materials.
• Martinex (Hyalrepair) is a therapeutic cosmetology company from Russia. Today it occupies one of the leading positions in the field of cosmetology and aesthetics in the domestic market. Produces peelings with rejuvenating, whitening, anti-inflammatory effects.
• NovoNexus (Repleri) is a group of scientists from Russia engaged in the production of innovative products in the field of health and beauty. The activity is patented by a company with the same name. Repleri intradermal implants for contour plastic surgery are especially in demand in cosmetology.

Biorevitalization of the face: reviews from doctors and patients

Over the past 10 years, the composition of drugs for mesotherapy and biorevitalization of the face has changed dramatically, and if earlier it was impossible to achieve express lifting, reducing the depth of wrinkles, and increasing collagen production, now this has become a reality. Of course, mono-preparations of hyaluronic acid can already be considered the last century of cosmetology. They are best used primarily in patients with a fine-wrinkled type of aging under the age of 25-30 years, who do not yet require intensive rejuvenation.

For patients with fine-wrinkle type of aging 30+, in addition to hyaluronic acid, vitamins (especially vitamin C), B vitamins, antioxidants that protect against photoaging, amino acids proline, glycine and lysine are very important to stimulate collagen production, cysteine ​​is to correct hyperpigmentation. Further 40-45+, peptides, nucleotides, and growth factors that stimulate collagen production are added to the above. Remember that it is better not to use HA more than once a month, i.e. you need to combine and alternate different drugs.

An important point - remember that in patients with deformational (edematous) type of aging, the use of HA, especially its high concentrations, will only aggravate swelling and deformation of the face, and increase gravitational ptosis. In such patients, it is very important to carry out capillary mesotherapy in the amount of 4-5 procedures, and to use preparations with nucleotides, peptides, amino acids, and vitamins as biorevitalizants. The use of GC in such patients is possible only in small concentrations of 0.3-0.5% and only at the final stage of treatment.

Let us say right away that there are very few qualified mesotherapists. Most people just want to quickly inject the patient with 1.0-2.0 ml of biorevitalizant and earn money. Almost no one is engaged in activating lymphatic drainage and blood supply to the skin of the face. That is why many patients have negative reviews of biorevitalization. They say it's expensive and the effect doesn't last long.

Bioreparation and biorevitalization: differences

Recently, in advertising of injection procedures for rejuvenation, the terms “bioreparation” and “biorestructuring” can increasingly be found. It’s just that each manufacturing company is trying to differentiate itself from others, and therefore they introduce new and new terms. Essentially, the term bioreparation means “restoration.” In my opinion, speaking objectively, bioremedies include preparations with nucleotides (DNA-RNA complexes), regulatory peptides and growth factors.

Which drug for biorevitalization is better to buy?

It is impossible to definitely name one best drug for rejuvenation and healthy skin. Each nominated candidate is unique in its advantages and properties, but at the same time, they all have disadvantages. The cosmetologist will tell you what to buy after identifying the client’s current problems, as well as the following results of the expert review:

• Teosyal Meso Expert is a universal remedy for women aged 25 years;
• Revi is a domestic product against alopecia with a prolonged action;
• Princess Rich – double long-lasting moisturizing effect;
• Hyamira is a universal remedy with a pronounced regenerating effect;
• Hyalrepair – the best combination of quality and price, long-lasting changes;
• Repleri are hypoallergenic biogels with the greatest demand on the European market.

The buyer has at his disposal the most modern drugs from the budget, mid-range and premium segments. In this matter, it is better to trust proven, reliable specialists who work daily with the represented companies and their products.

Non-injection biorevitalization: reviews

The administration of medicinal substances can also be carried out using a non-injection method - by pulsed iontophoresis. The fact is that the permeability of the skin for molecules of large molecular weight (hyaluronic acid, amino acids, vitamins) is minimal, and in order to somehow increase it, pulsed discharges of weak electric current are used. A biorevitalizant solution is first applied to the skin. The procedure lasts about 45 minutes. The course consists of 6-8 procedures over 2 weeks. A repeat course is carried out after half a year.

Reviews for non-injection biorevitalization are mostly negative, which is due to the low efficiency of the method and the inability to introduce therapeutically effective concentrations of active substances into the skin. On the other hand, this technique reduces the risk of developing an infection and also eliminates the possibility of scars appearing at the site of skin punctures with a needle, which happens in patients with a tendency to ankylosis.

Before the first procedure, a microdermabrasion session must be performed, or one of the special enzyme masks must be applied. This will remove superficial dead skin cells and increase skin permeability to medicinal components. We hope that our article on the topic: Biorevitalization of the face before and after, effect, reviews – turned out to be useful to you!

Sources:

1. Add. professional

, 2. Personal experience of clinical application, 3. National Library of Medicine (USA), 4. The National Center for Biotechnology Information (USA), 5. “Aesthetic mesotherapy” (Tochinova N.A.).

Affordable and safe rejuvenation technique

Biorevitalization is an injection technique aimed at rejuvenating and slowing down the aging process. The procedure is based on the use of hyaluronic acid, a substance found in epithelial and connective tissue. It nourishes and moisturizes the skin, tones, fills with energy, eliminates wrinkles and pigmentation. Already after the first session, metabolic processes and blood circulation improve, and the production of hyaluronic acid and collagen increases.

Other advantages of the technique include:

• Safety. Hyaluronic acid is part of the tissues of the human body, so the procedure is well tolerated. The recovery period does not last long, and no adverse reactions occur.
• No pain. The drug is injected under the skin with a thin needle through small punctures, so the procedure is practically painless. If you have sensitive skin, use an anesthetic cream.
• Durability of the result. The effect lasts for 6-12 months.

Combination of biorevitalization with other methods

1. Biorevitalization with Ial System / Ial System and Ial System ACP drugs goes well with superficial chemical peeling. After biorevitalization with Ial System 1.1, a chemical peeling procedure is performed on the 10th day. Exposure time and drug concentration are selected individually. On the 5th day after it, if the optimal level of moisture is achieved, biorevitalization is carried out with the drug Ial-System ACP. On the 10th day, chemical peeling is repeated, on the 5th day after it, the Ial System ACP procedure is performed, after 10-14 days, chemical peeling again. This combination allows you to normalize the synthesis of hyaluronic acid and collagen in the dermis, remove hyperkeratosis, pigmentation, and reduce the depth of wrinkles.

2. Biorevitalization and laser facial rejuvenation. After the fractional laser rejuvenation procedure, biorevitalization is carried out on the 14th day in order to restore the water balance of the dermis, necessary for cell division and differentiation. The use of biorevitalization allows you to shorten the rehabilitation period and get excellent results in the shortest possible time.

3. Biorevitalization and photorejuvenation potentiate each other’s action. The interval between these procedures should be 10 days. In case of rosacea, it is advisable to complete the program with a photorejuvenation procedure.

A universal treatment regimen for age-related skin changes

1. Pre-peeling preparation in combination with biorevitalization.
2. Peeling.
3. Post-peeling rehabilitation in combination with biorevitalization.
4. Botulinum toxin.
5. Contour plastic.

Recommendations for skin care after the biorevitalization procedure

1. During the first 24 hours after the procedure, it is not recommended to apply cosmetics and makeup; the use of the drug “Curiosin” and “Traumeel S” is allowed.
2. Postpone visiting the solarium for 10-14 days, saunas and steam baths - for a week.

Contraindications to the Ial System biorevitalization procedure

• hypersensitivity to hyaluronic acid;
• pregnancy and lactation;
• active inflammatory process in the treatment area of ​​any origin;
• tendency to form hypertrophic and keloid scars;
• taking blood thinning medications (aspirin, heparin, etc.);
• severe somatic diseases (diabetes mellitus, autoimmune processes, crisis course of hypertension, etc.);
• previously introduced synthetic implants in the treatment area.

Due to the high risk of post-inflammatory hyperpigmentation, it is not recommended to carry out the procedure earlier than 2 weeks after returning from active sun.

Using Ial System ACP and Ial System in the same procedure

The essence of the combination is the simultaneous use of two drugs, which makes it possible to use each drug in the area where it is especially needed. Ial System ACP is injected into the area around the eyes, 3-4 mm away from the ciliary edge, using microinjections using the “point by point” technique. The same technique is used on the upper eyelid. The area around the eyes is characterized by swelling, which is not a contraindication to this drug. Ial System ACP is also recommended to be administered to seborrheic areas, as it significantly reduces sebum secretion. It stimulates collagen synthesis more actively and remains in tissues longer, and the clinical effect lasts 4-6 months. All other areas are treated with the Ial System, including the neck and décolleté area. The biorevitalization procedure using two drugs is carried out once a month. The number of procedures for an intensive course ranges from 2 to 4, depending on the individual characteristics of the skin, age and maintenance of the menstrual cycle.

Maximum stimulation of fibroblasts after biorevitalization is observed from 5 to 14 days. Fibroblasts are hormone-dependent skin cells, and their activity is directly related to the concentration of estrogen during the menstrual cycle in women. The maximum level of estrogen is observed on days 12-14 of the cycle. The combination can be considered optimal when the 5th day after the biorevitalization procedure corresponds to the 12-14th day of the menstrual cycle. That is, you can achieve maximum stimulation of fibroblasts by performing the biorevitalization procedure on days 7-9 of the menstrual cycle. This is especially true for premenopausal women, i.e. during the initial period of decreased ovarian function. Endocrinologically, this period is characterized by a decrease in estrogen concentration, and clinically by a change in the interval between menstrual cycles. Premenopause begins at the age of 42-45 years, its duration is from 2 to 10 years.

Biorevitalization course Ial System

A) Patients are under 30 years of age.

The course is carried out to increase skin turgor in people who abuse tanning, to prevent photoaging, before traveling to hot countries and 2 weeks after returning, as well as to correct premature wrinkles in patients with dry skin with sudden weight loss. This group uses Ial System monotherapy.

B) Age from 30-45 years.

The course is carried out with the aim of increasing skin turgor and elasticity, restoring its adaptive properties. And also during the rehabilitation period after chemical peels, laser rejuvenation, phototherapy. The primary course includes 2 Ial-System procedures, after 2 weeks Ial-System ACP, a month later - the second Ial-System ACP procedure. Maintenance course - Ial System ACP or Ial System every 4-5 months.

B) Age after 45 years.

The course is carried out with the aim of replenishing the deficiency of hyaluronic acid in the dermis, stimulating fibroblasts, and restoring microcirculation. The primary course includes 2 Ial System procedures once every 2 weeks, after 2 weeks - Ial-System ACP, after a month - again Ial System ACP. Repeated course - injections of Ial System ACP are carried out at intervals of 3-4 months. In patients with dry skin, the scheme of simultaneous administration of two drugs once a month has proven itself to be effective.