What causes skin pigmentation disorders?
Bibliography
1 GRLS, r/u LP-004175 dated 03/03/2017
2 Certificate GMP-0036-000221/18
3 Greveling K, Prens EP, Ten Bosch N, van Doorn MB. Comparison of lidocaine/tetracaine cream and lidocaine/prilocaine cream for local anesthesia during laser treatment of acne keloidalis nuchae and tattoo removal: results of two randomized controlled trials. Br J Dermatol. 2016 Jul 5. doi:10.1111/bjd.14848 Hernandez E.;
4 J. Cassuto, R. Sinclair, M. Bonderovic, Anti-inflammatory properties of local anesthetics and their present and potential clinical implications. Acta Anaesthesiol Scand 2006; 50; 265-282]
5 Based on IQVIA report March 2022 - September 2022
6 Russian medical journal. Zhigultsova T.I., Parkaeva L.V., Ilyina E.E., Vissarionov V.A.: “Experience of using 5% Emla cream in the practice of dermatocosmetologists”
7 Instructions for use of the medicinal product for medical use Acriol Pro
8 T.N. Calvey, N.E. Williams. Pharmacology for anesthesiologists. Publishing house Binom, Moscow, 2007, 119-128
9 Based on the report “Anesthetics in injection cosmetology for 2016” Vademecum Analytical Center for sales volume.
10 T.I. Zhigultsova, Ph.D. L.V. Parkaeva, E.E. Ilyina, professor V.A. Vissarionov: “Experience of using 5% Emla cream in the practice of dermatocosmetologists” Cosmetology and plastic surgery. Vol. 16, No. 9, 2008
11 On the Russian market there are so-called cosmetic products containing lidocaine and not registered as medicines
12 Cling film can be used as an occlusive dressing
13 Drug Release Studies on an Oil-Water Emulsion Based on a Eutectic Mixture of Lidocaine and Prilocaine as the Dispersed Phase
14 Federal Law-61 “On the Circulation of Medicines” dated April 12, 2010, Federal Law-323 “On the Fundamentals of Protecting the Health of Citizens in the Russian Federation” dated November 21, 2011 and Federal Law-532 “On Amendments to Certain Legislative Acts of the Russian Federation Regarding Counteraction to Trafficking falsified, counterfeit, substandard and unregistered medicines, medical devices and counterfeit dietary supplements" dated December 31, 2014.
15 Federal Law-532, Technical Regulations of the Customs Union on the safety of perfumery and cosmetic products, Federal Law 61, Federal Law 532, Criminal Code of the Russian Federation, Art. 235, 238, 227
16 V.V. Osipova.MMA named after. I.M. Sechenov. Psychological aspects of pain. Lecture. №1/2010
17 According to GMP News. Analysis of the market for local anesthetics used in cosmetic injections in 2022.
18 One type of occlusive dressing, namely: bandage, cling film, adhesive tape or rubberized fabric
19 The combination of lidocaine and prilocaine in concentrations above 0.5-2% has bactericidal and antiviral properties. In Akriol Pro the concentration is 5%.
20 A.A. Stepanov, G.V. Yatsyk, L.S. Namazova Method of preventing pain in young children during vaccination // Into the practice of pediatricians - 09.14.2006 -
21 N.V. Klipinina, RMJ, Some features of the perception and experience of pain by children: a psychologist’s view, reprint. 2007.1-7
22 E.A. Ranneva. The use of EMLA® cream in the complex correction of cosmetic imperfections. Experimental and clinical dermatocosmetology 2010, No. 2: 48-53.
23 Gonzalez S. Evaluation of Topical Anesthetics by Laser-Induced Sensation. Lasers in Surgery and Medicine 23:167–171(1998));
24 V.G. Lebedyuk et al. Anesthesia in dermatocosmetology. Experimental and clinical dermatocosmetology, 2010 No. 5
25 Meltem F. Söyleva Nilüfer Koçaka Bahar Kuvakia Seyhan B. Özkanb Erkin Ki˙rb; Anesthesia with Cream for Botulinum A Toxin Injection into Eyelids. Ophthalmologica 2002;216:355–358
26 E.V. Matuszewska and authors. Topical local anesthetics in cosmetology. Clinical Dermatology and Venereology. 03.2017 pp. 89-96
27 Therapeutics and Clinical Risk Management 2006:2(1) 99 – 113
28 F. Michael Ferrante, Timothy R. Wade Bopcore Postoperative Pain. Management. Per. from English/Ed. M.: Medicine, 1998.- 640 pp., p. 243
29 Lakhin R.E. Local anesthetics. Department of Anesthesiology and Reanimatology of the Military Medical Academy named after. S.M.Kirova, St. Petersburg, 2013, Committee on Ultrasound Technologies of the All-Russian public organization “Federation of Anesthesiologists and Resuscitators.” Clinical guidelines “Intensive therapy for systemic toxicity with local anesthetics. Moscow - St. Petersburg 2015 Page. 10 https://www.far.org.ru/recomendation
30 Wetter DA et al. J American Acad. Dermatol. 2010;63(5):789-98
31 https://www.1nep.ru/articles/issledovanie-sostava-populyarnykh-mestnykh-anestetikov/
32 ORDER OF THE MINISTRY OF HEALTH OF THE RUSSIA dated 08.10.2015 No. 707n
33 Davydov O.S. Peripheral and central mechanisms of the transition of acute pain to chronic pain and the possible role of cyclooxygenase 2 inhibition in the prevention of chronic pain syndrome. Neurology, neuropsychiatry, psychosomatics. 2016;8(2):10-16.
34 J. ALASTAIR CARRUTHERS, MD, JEAN DA CARRUTHERS, MD. Safety of Lidocaine 15% and Prilocaine 5% Topical Ointment Used as Local Anesthesia for Intense Pulsed Light Treatment. Dermatologic Surgery 2010;36:1130–1137
35 Ya-Xian et al. The number of cells in the stratum corneum of normal skin depending on the anatomical location on the body, age, gender and physical parameters Archives Dermatol Res 1999; 291:555–559.
36 J. Morgan, Magid S. Michael. Clinical anesthesiology, Book 1. Binomial. Moscow St. Petersburg, 2001
37 Arendt-Nielsen L, Bjerring P, Nielsen J. Acta Derm Venereol 1990;70:314-318
38 Belarusian State Medical University. 2nd Department of Therapeutic Dentistry. Therapeutic dentistry. Part 1. Ed. A.G. Tretyakovich, L.G. Borisenko.
39 Dermatol Surg 1999;25:950-954
40 K. Greveling et al. Br J Dermatol 176(1), 81-86. 2016 Dec 10
41 Juhlin and Evers Adv Dermatol 1990;5:75-92
42 Arendt-Nielsen L, Bjerring P, Nielsen J. Acta Derm Venereol 1990;70:314-318
43 Study Desensor 001. Wahlgren CF, Quiding H. J Am Acad Dermatol 2000;42:584-8.
44 https://www.1nep.ru/estetic/articles/13952/
45 Guide to dermatocosmetology, edited by E.R. Arabia and E.V. Sokolovsky. St. Petersburg: Foliant Publishing House LLC, 2008 - 632 pp.
46 https://www.1nep.ru/estetic/articles/132197/
47 https://medside.ru/dikain
48 https://medi.ru/instrukciya/novokain_9473/
49 https://medside.ru/anestezin
50 https://grls.rosminzdrav.ru/Default.aspx
51 Radman et al.2002, Yamashita., 2003
52 https://www.krasotaimedicina.ru/diseases/hematologic/methemoglobinemia
53 Evers H, Scott B, Dahlquist AC. Dermal analgesia after epicutaneous application of 5% cream, 5% prilocaine cream, 5% lidocaine cream and placebo cream, to volunteers. Study 89EM03 (n= 21, cross-over). CSR 802-10AC088-2,1989.
54 MASMI. A study of users of skin anesthetics. June 2018
55 O.M. Burylina, A.V. Karpova. Cosmetology. Clinical guidelines. GEOTAR-Media. Moscow, 2018
56 Postoperative pain: the role of peripheral and central sensitization mechanisms. https://rsra.rusanesth.com/publ/posleoperatcionnaya_bol.html
57 Paul M. Friedman, MD, Jushua P. Fogelman, MD and others. Comparative Study of the Efficacy of Four Topical Anesthetics. Dermatolog Surg 1999; 25:950-954
58 https://www.1nep.ru/articles/rynok-kosmeticheskikh-anestetikov-dlya-kozhi/
59 https://www.rlsnet.ru/mnn_index_id_879.htm
60 https://yandex.ru/health/pills/product/ultrakain-ds-2195
61 https://grls.rosminzdrav.ru/Default.aspx on 02/15/2021
62 Ziganshin O.R. Comparison of the effectiveness and safety of topical local anesthetics for superficial surgical interventions in dermatology. Clinical dermatology and venereology. 2018;17(6):53-60. https://doi.org/10.17116/klinderma 20181706153
63 Comparison of Topical Anesthetics for Radiofrequency Ablation of Achrocordons: Eutectic Mixture of Lignocaine/Prilocaine versus Lidocaine/Tetracaine Pratik Gahalaut,1 Nitin Mishra,1 Sandhya Chauhan,2 and Madhur Kant Rastogi11Department of Dermatology, Venereology and Leprosy, Shri Ram Murti Smarak Institute of Medical Sciences, Nainital Road, Bareilly 243001, India2Department of Pediatrics, Shri Ram Murti Smarak Institute of Medical Sciences, Nainital Road, Bareilly 243001, India
64 https://www.gazeta.ru/science/2012/11/01_kz_4837701.shtml
65 https://www.kp.md/daily/23716.3/53610/
66 https://doktorbel.livejournal.com/29873.html
67 https://politeka.net/zdorovye/870023-uchenye-vyjasnili-kak-muzhchiny-i-zhenshhiny-zapominajut-bol-kto-vynoslivee/
68 https://spacefacts.ru/news/people-and-medicine/psychology/792-udovolstvie-ili-bol.html
69 https://tattooinfo.ru/raznoe/foto-prokolotoj-guby-vidy-kak-delat-uxod-za-mestom-prokola.html
70 https://tatuazhpro.ru/pirsing/indastrial.html
71 https://sprs-therapy.ru/faq/V-kakih-sluchayah-nuzhno-primenyat-SPRS-terapiyu_i-v-kakih-nelzya
72 https://sprs-therapy.ru/faq/Kakim-obrazom-provoditsya-SPRS-terapiya
73 https://cosmetology-info.ru/6425/Metody-udaleniya-vtorogo-podborodka/
74 https://beauty.net.ru/public/inektsionnaya_konturnaya_plastika_nososleznoy_borozdy/
75 https://www.1nep.ru/articles/131016/
76 Morrison A.V., Bocharova Yu.M., Morrison V.V. Botulism toxin - a therapeutic effect in cosmetology (review). Saratov Scientific and Medical Journal 2016; 12(3):521–524.
77 A.V. Gara, V.G. Zolotareva, Features of botulinum therapy for aesthetic indications for patients over 45 years old, Injection methods in cosmetology No. 4-2011 – 54-60 s
78 Methodological manual on mesotherapy for students of postgraduate and additional professional education. / Shamov B.A., Dyadkin V.Yu., Zhelonkina T.I./ – Kazan: KSMU, 2011. – 60 p.
79 https://www.1nep.ru/estetic/articles/119953/
80 Evers H, Scott B, Dahlquist AC. Dermal analgesia after epicutaneous application of EMLA 5% cream, 5% prilocaine cream, 5% lidocaine cream and placebo cream, to volunteers. Study 89EM03 (n= 21, cross-over). CSR 802-10AC088-2,1989.
81 https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=overview.process&ApplNo=019941
82 Superficial, medium or deep peeling: what to choose - https://medbooking.com/blog/post/
83 Features of medium peels – https://www.1nep.ru/estetic/articles/190169/
84 Facial peeling – https://cosmetology-info.ru/668/Piling-litsa/
85 Plastic surgery of cheekbones with fillers – https://cheap-fillers.ru/articles/plastika-skul-fillerami
86 Ozone therapy (O3) for the face - a revolutionary beauty technology - https://plastichno.com/cosmetology/ozonoterapiya-dlya-litsa#i-7
87 Effective face lift with liquid mesothreads: what is it and what are the popular brands? – https://beautyexpert.pro/kosmetologiya/inektsionnaya/tredlifting/vidy-nitej/zhidkie-mezoniti.html
88 Mesotherapy of the periorbital area using peptide cocktails – https://www.manuolog.ru/info/about/articles/stati-po-kosmetologii/mezoterapiya-periorbitalnoy-oblasti-s-primeneniem-peptidnykh-kokteyley/
89 Enzyme hair removal: getting rid of excess vegetation – https://plastikaplus.ru/kosmetologiya/epilyaciya/enzimnaya.html
90 Liquid mesothreads and traditional threadlifting: advantages and disadvantages – https://aesthetic-futures.com.ua/zhidkie-mezoniti-i-tradicionnyj-tredlifting-preimushhestva-i-nedostatki
91 Cannula in cosmetology and medicine – https://ladysdream.ru/kanyulya.html
92 7 myths about anesthesia: what are we afraid of? – https://www.psychologies.ru/articles/7-mifov-o-narkoze-chego-myi-boimsya/
93 Medium peeling - an uncompromising method of rejuvenation - https://plastichno.com/cosmetology/sredinnyj-piling#i-3
94 Khunger N. Standard guidelines of care for chemical peels. Indian J Dermatol Venereol Leprol 2008;74(Suppl):S5-S12 – https://pro.bhub.com.ua/cosmetology/himiceskie-pilingi-standartnye-rekomendacii-po-primeneniu#
95 Kim Lawless - 10 secrets of successful hair removal - https://www.cosmo.ru/beauty/body/10-sekretov-udachnoy-epilyacii/
96 All about Sugaring - https://www.gabbi-shugaring.ru/vse-o-shugaringe#rec61612476
97 Hirsutism – https://www.krasotaimedicina.ru/diseases/zabolevanija_endocrinology/hirsutism
98. Intralesional interferon therapy for recurrent warts, G. E. Bagramova, T.G. Sedova, A.N. Khlebnikova // Russian Journal of Skin and Venereal Diseases No. 1, 2013 – 23-26 p.
99. Korolkova T.N., Goma S.E. Study of the effect of mesotherapy with pineal gland peptides on skin moisture and elasticity, Russian Journal of Skin and Venereal Diseases. 2017; 20(5) – 305-310 p.
100. S.V. Klyuchareva, S.M. Nikonova, I.V. Ponomarev, Laser treatment of benign pigmented skin tumors, experimental and clinical dermatocosmetology No. 3, 2006 – 22-31 p.
101. Photorejuvenation in the complex correction of age-related skin changes, N.I. Tsisanova, Journal of Applied Aesthetics No. 1, 2007
102. https://plastichno.com/cosmetology/fotoomolozhenie
103. Current state of the problem of human papillomavirus infection / L. A. Yusupova, E. I. Yunusova, Z. Sh. Garayeva, G. I. Mavlyutova, K. A. Salakhutdinova // Attending physician No. 7/2019; Page numbers in the issue: 64-67 – https://www.lvrach.ru/2019/07/15437345
104. Human papillomavirus infection of the genitals in women, S.I. Rogovskaya, V.N. Prilepskaya, E.A. Mezhevitinova, M.N. Kostava // Bulletin of Dermatology and Venereology, N 6-1998, pp. 48-51. – https://nature.web.ru/db/msg.html?mid=1178539&uri=index.html
105. https://www.1nep.ru/estetic/articles/183501/
106. https://www.1nep.ru/articles/208888/
107. https://cosmetology-info.ru/6925/salon-procedures-Lipolitiki-dlya-litsa/
108. https://www.1nep.ru/articles/204894/
109. https://www.verywellhealth.com/stratum-corneum-anatomy-1069189
110. Turkin P.Yu., Rodionov S.V., Somov N.O., Mirgatia I.O. Venous trophic ulcers: current state of the issue // General Medicine. 2022. No. 1. URL: https://cyberleninka.ru/article/n/venoznye-troficheskie-yazvy-sovremennoe-sostoyanie-voprosa
111. Kruglova Larisa Sergeevna, Panina Anastasia Nikolaevna, Strelkovich Tatyana Igorevna Trophic ulcers of venous origin // Russian Journal of Skin and Venereal Diseases. 2014. No. 1. URL: https://cyberleninka.ru/article/n/troficheskie-yazvy-venoznogo-geneza
112. Yu.M. Stoiko, A.I. Kirienko, I.I. Zatevakhin, A.V. Pokrovsky, A.A. Karpenko et al., Russian clinical guidelines for the diagnosis and treatment of chronic venous diseases // Phlebology No. 3, 2022 – 143-240 pp. — https://webmed.irkutsk.ru/doc/pdf/ven2009.pdf
113. Dovnar R.I., Smotrin S.M. Trophic ulcers of the lower extremities: modern aspects of etiology and pathogenesis // Journal of GrSMU. 2009. No. 4 (28). URL: https://cyberleninka.ru/article/n/troficheskie-yazvy-nizhnih-konechnostey-sovremennye-aspekty-etiologii-i-pathogeneza
114. Burleva E.P., Babushkina Yu.V. Experience in outpatient treatment of trophic foot ulcers that complicated the course of diabetes mellitus // Hospital-replacing technologies: Outpatient surgery. 2022. No. 3-4. URL: https://cyberleninka.ru/article/n/opyt-ambulatornogo-lecheniya-troficheskih-yazv-stop-oslozhnivshih-techenie-saharnogo-diabeta
115. Kutsenko I.V., Andrashko Yu.V. Conservative treatment of trophic ulcers of the lower extremities in chronic venous insufficiency // Methodological recommendations. 2007. https://medinfo.center/wp-content/uploads/2019/12/metodichka-tya.pdf
116. Trophic ulcers of the lower extremities in outpatient clinic practice//Methodological recommendations for fourth-year students of the Faculty of Medicine. 2020 https://rsmu.ru/fileadmin/templates/DOC/Faculties/LF/fsurg2/algoritm_dignost/UP/3._UP_Troficheskie_rasstroi__stva_kozhi_nizhnikh_konechnostei__.pdf
117. Russian clinical guidelines for the diagnosis and treatment of chronic venous diseases. Phlebology, issue No. 2. 2013 https://www.mrckb.ru/files/flebologii.pdf
118. I. L. Mikitin, G. Z. Karapetyan, L. V. Kochetova, S. V. Yakimov, R. A. Pakhomova Modern view on the treatment of trophic ulcers // Creative surgery and oncology. 2013. No. 4. URL: https://cyberleninka.ru/article/n/sovremennyy-vzglyad-na-lechenie-troficheskih-yazv
119. Aralova M.V. Personalized technology for regional treatment of patients with trophic ulcers of the lower extremities. dis. for the academic degree of Doctor of Medical Sciences Voronezh, 2019
120. Lok et al. J Amer Acad Derm 1999;40:208-13. (Study EM9405)
121. Hansson C et al. Acta Derm Venereol (Stockh) 1993;73:231-233.
122. Order of the Ministry of Health of Russia dated October 13, 2017 No. 804n “On approval of the range of medical services.
123. Order of the Ministry of Health dated October 8, 2018 No. 707n “On approval of qualification requirements for medical and pharmaceutical workers with higher education in the field of training “Health and Medical Sciences”
124. 124. Starostina L.S. Helping control pain in children: advice from a pediatrician. Medical advice. 2021;(1):263–268. doi: 10.21518/2079-701X-2021-1-263-268
Pigmentation (hyperpigmentation) in adults and children
People often wonder why and what causes pigment spots to appear on the body. There can be quite a few reasons, most of them will be answered in our article. Heredity may be a major factor. In such cases, visual defects appear from birth or at a very young age, because information about them is embedded in the DNA.
Therefore, there is no big difference when a person decides to deal with the problem. In the most extreme situations, when this seriously spoils the appearance, and, consequently, the quality of life, treatment with modern surgical techniques, for example, laser resurfacing, is indicated. However, these are extreme measures, and alternative options can always be found. Laennec Skincare – LNC offers to transform the skin at the cellular level, prevent and completely eliminate hyperpigmentation.
2.Types of skin changes
Most skin changes - growths, bumps, warts, moles, spots, rashes - are harmless. Some of them, such as moles, gradually appear on the skin from the moment a person is born. Others may be associated with local exposure to aggressive factors on the skin, allergic reactions, the aging process and diseases of internal organs. Let's take a closer look at the most common skin changes:
Moles or birthmarks.
Moles are dark brown or brown colored growths that vary in shape, size and structure. Moles contain melanin or melanocyte cells. Human life, starting from infancy, is accompanied by the appearance of birthmarks on the skin, which is a completely natural phenomenon. In very rare cases, a child is born with moles already present on the skin. Most often, moles are a harmless phenomenon that does not require treatment. But a change in the color and size of the birthmark, its elevation above the surface of the skin may indicate its transformation into a malignant tumor. It is recommended to immediately consult a dermatologist if you notice the growth of a mole, a change in its color and shape, as well as bleeding from the place where the birthmark was previously located.
Acne and pimples.
Acne is a common inflammatory skin disease associated with damage to the sebaceous glands. There are several types of acne, differing in appearance and other features. However, in most cases, acne has a common cause - disruption of the sebaceous glands, accompanied by excessive production of sebum. Pimples, like acne, most often appear on the skin of a person’s face and body during adolescence, gradually disappearing with age. However, there are people who suffer from acne and acne throughout their lives.
Pigmentation.
Skin pigmentation occurs due to the functioning of pigment cells, which can become darker in color than other areas of the skin.
For women, increased pigmentation, or chloasma
- focal hyperpigmentation of the skin - is especially characteristic during pregnancy. Experts believe that skin pigmentation during pregnancy is associated with a woman’s hormonal levels. Therefore, doctors recommend that pregnant women reduce their time in the sun and use special sunscreens to protect their skin.
Actinic keratosis and senile warts.
Their formation occurs in stages, mainly in open areas of the body. These warts are common in older people and, unlike other types of warts, they are not caused by the papilloma virus. How does actinic keratosis occur? Initially, yellow-brown protruding flat layers with unclear outlines appear on the skin. Over time, they turn into nodules and papules that rise slightly above the surface of the skin. At the final stage of transformation into senile warts, they darken, increase in size and become crusty. The main cause of aging warts is overexposure to the sun, so if you notice such spots, you can prevent their deformation by protecting these areas of the skin from the sun's rays.
Itching, rash and hives.
Such skin changes are the main sign of the development of allergies. Itchy skin and rashes can appear as a result of taking medications, using low-quality cosmetics, etc.
Visit our Dermatology page
Treatment
There are various methods to get rid of unwanted coloring. Their choice should primarily depend on the pathology itself, the person’s age, and whether he or she has any other problems. Therefore, first of all, it is necessary to carry out a competent diagnosis, which is impossible without special equipment and experienced specialists.
Cosmetical tools
If the unwanted coloring is not a consequence of any disease, then you can use some cosmetic preparations. Effective creams and masks usually contain:
- parsley or jojoba extract;
- arbutin;
- kojic acid;
- vitamin C;
- hydroquinone.
It would be worth repeating that you should use any means only after consulting a doctor.
Cosmeceuticals
In addition to cosmetics, you can purchase effective, safe and high-quality placental preparations to eliminate various skin defects.
- Bb Laboratories - the line is highly effective due to the combination of biologically active substances, peptides, herbal extracts, hyaluronic acid and other components.
- GHC Placental Cosmetic is a series of products that saturates cells with beneficial biologically active compounds, activates the synthesis of collagen and elastin fibers, improves the regeneration process, and reduces wrinkles.
- PlaReceta & PiloPla - the line fights the signs of facial aging, restoring the dermis. The products are especially aimed at those with sensitive, dehydrated, flaky skin, providing effective care and maintaining youth.
- LAENNEC SkinCare - LNC is a placental and vitamin line aimed at eliminating age-related changes. It also helps in restoring the condition of the skin after photodamage. The products restore an even complexion, improve the condition of the skin during inflammation and prevent the formation of wrinkles.
Anti-age drugs
Bb Laboratories – Hyaluron-elastin-collagen extract
Laennec – solution for injection
Curacen Essence (20 fl x 2 ml)
Two-phase placental serum concentrate
Laser skin resurfacing
Often, girls and women choose similar salon procedures that help to quickly and without a trace cope with certain types of skin defects. The laser penetrates deeply into the epidermis and destroys melanin, eliminating everything quickly and safely. Problems usually do not arise after such “cleaning”, but you should only contact reliable and trusted specialists.
Face and body
There are a huge number of different reasons why skin hyperpigmentation appears. It can occur not only on the surface of the face, but also on the arms, back, legs, and abdomen. This may be due to genetics, various autoimmune disorders, excessive uncontrolled exposure to ultraviolet rays, insurmountable external circumstances, for example, the climatic characteristics of the region of residence, the environmental component, smoke or dust in cities.
Darkening on the stomach or back, on the arms or legs can appear after an inflammatory process in the epidermis. For some, insect bites cause light or dark areas of varying sizes that last a long time. Why is this happening? There are many prerequisites, they are worth discussing separately.
Causes of age spots on the body
The mechanism is simple - melanocytes participate in tissue healing, help rapid regeneration, and stop oxidation from the effects of free radicals. However, “working” on a certain place, they at the same time significantly darken it, which is why a stain is formed.
Problems with improper redistribution of melanin can arise with long-term use of certain medications. In the process of treating one imperfection, a person also earns an additional one - ugly darkened or light areas. Antibiotics and oral contraceptives also sometimes cause different types of darkening of the surface of the dermis.
Anti-age drugs
Curacen Essence (20 fl x 2 ml)
Laennec – solution for injection
Bb Laboratories – Serum “Arcanum”
Premium set “Ideal facial skin. Healthy tone"
