What is the difference between direct and indirect lipolytics

From this article you will learn:

  • how is mesotherapy for weight loss performed,
  • reviews, before and after photos,
  • how much does mesotherapy cost - the price of the procedure (for 2022).

Mesotherapy can be used not only to prevent or correct age-related skin changes (for example, on the face and neck), but also to correct local fat deposits and cellulite. Injections of mesopreparations can reduce the volume of adipose tissue in local areas - on the body this is most often the abdomen, waist, thighs, arms, and armpits. On the face and neck, you can reduce the volume of the double chin, lower third of the face, jowls, and also work with fat bags in the eyelids and nasolabial folds.

Body mesotherapy for weight loss includes the use of 3 groups of drugs. The first group is vascular and drainage drugs that allow you to activate microcirculation and lymphatic drainage. The second main group is the so-called “lipolytics”, most of which work to empty fat cells (that is, remove fatty acids from them), but some are capable of irreversibly destroying fat cells. And in order to tighten the skin later, at the third stage, drugs with a lifting effect are used.

Abdominal mesotherapy for weight loss –

But patient reviews of mesotherapy are not always positive and excellent. As a rule, this is due to the fact that, in order to save time, mesotherapists often do not comply with the standards of working with local fat deposits. For example, the need for lymphatic drainage vascular injection (capillary mesotherapy) is often ignored in order to activate lymphatic drainage and microcirculation. Below are a few words about why this is a very important stage and cannot be skipped.

Due to lifestyle (sedentary work, lack of regular sports activities), absolutely all patients who turned to a mesotherapist for local fat deposits have impaired microcirculation and lymphatic drainage. And against the background of this, we begin to put lipolytics into the subcutaneous fat tissue, and then the following happens - the fat cells are emptied, and the fatty acids contained in them enter the intercellular space. But lymphatic drainage does not work, and therefore fatty acids are not excreted, remaining in the intercellular fluid, and then the following happens - fat cells begin to reabsorb them.

Important: therefore, mesotherapy for weight loss should always include lymphatic drainage vascular injection - both main and local areas. This is the first important rule that will make the course of treatment more effective. The second point is the correct choice of lipolytics, because the strongest lipolytics are not always good for the patient, because they cause fibrosis of subcutaneous fat. Well, the third point is that the effectiveness of lipolytic administration depends on the administration method (for example, using a cannula will be 30-40% more effective when compared with needle administration).

How is mesotherapy for weight loss carried out?

The classic course of correction of body fat always consists of three stages: 1) lymphatic drainage vascular injection, 2) the main stage - the use of lipolytics, 3) skin tightening. The total number of procedures will depend on the volume of fat deposits - usually 10-12 procedures, carried out once a week. But for very obese people weighing from 100 to 150 kg, one such course will not be enough, and they will need 3-4 times more procedures.

In addition, different patients may respond completely differently to treatment. When using the same treatment regimens and the same medications, the effect in some patients can be clearly noticeable after several procedures, while in others it can be almost unnoticeable. Those. Individual characteristics (hormonal levels, dietary habits, age) play a large role. For example, in women with age, the number of beta receptors responsible for the activation of lipolysis decreases on the membranes of fat cells, and therefore the effectiveness of many lipolytics decreases sharply.

Recommended drugs (by stages) –

Below we will describe in detail the content of each stage, and which mesotherapy drugs and their combinations should be used. Moreover, this standard course of therapy is applicable for the correction of any local fat deposits on the body (regardless of the zones), i.e. it is suitable for mesotherapy of the abdomen, thighs, and fat deposits of other localizations.

Composition and types of drugs

Direct lipolytics contain substances that destroy the cell walls of adipocytes. The list of active components of meso-cocktails for weight loss includes:

  • Phosphatidylcholine;
  • Sodium deoxycholate;
  • MRX complex containing levocarnitine, dandelion extract, lidocaine, benzpyrone.

Phosphatidylcholine is a direct lipolytic from the group of lecithins. The molecule consists of choline and 2 types of fatty acids. Contained in soybeans, eggs, mustard seeds.

Activates redox processes in the body, regulates protein, lipid and energy metabolism.

Deoxycholate is a substance that enhances the effect of phosphatidylcholine. In the body it is naturally present in bile. Breaks down fats during food digestion, acting on intermolecular bonds. Removes excess fluid from the body.

The MPX complex destroys adipocyte membranes and binds organic acids. Reduces swelling, pain and inflammation, improves microcirculation in tissues.

The first stage is lymphatic drainage vascular injection

Lymphatic drainage vascular injection (synonym – capillary mesotherapy) is the first stage, which can be called “preparation”. Usually at this stage 3 procedures are enough, but for very obese people it is advisable to stretch this stage even up to 10 procedures. The use of vascular and drainage drugs at this stage will allow us to activate lymphatic drainage, eliminate congestion, increase the tone of capillary walls, and improve tissue trophism. This stage is very important not only for weight loss programs, but also in the treatment of cellulite and varicose veins.

Lymphatic drainage vascular puncture can be main and local (according to problem areas), and we will deal with both. At the beginning of each stage 1 procedure, we perform a main vascular puncture of the body, for which you can use the ready-made combined preparation “GAG Complex DVL Capyl” - based on gingo biloba extract and troxerutin. But it would be even better to add a few ml of a drug with more pronounced drainage properties - “Artichoke” or “Rutin + melilot extract”.

Examples of drugs –

Areas for the main vascular injection of the body are injections along the midline and paravertebral lines along the spine, as well as injection lines along the outer and inner surfaces of the thighs and legs, as well as in the calf muscles. Additionally, several lines of injections can be made along the back of the thighs, if necessary. We must spend about 5.0 ml of the drug on the main vascular injection.

Working with zones - the second part of each stage 1 procedure includes working with one of the local zones (for example, the stomach). If the volume of fat deposits is small, then you can work on 2 zones at once, for example, the stomach and inner thighs. In our opinion, the optimal preparation for working with zones at stage 1 is “GAG complex DVL E”, consisting of troxerutin, plant extracts of ginkgo biloba, artichoke and yohimbine. This drug has a vascular and drainage effect, but thanks to the soft lipolytic Yohimbine, it also acquires a moderate lipolytic effect.

We can spend another 10 ml of the drug to work with 1 local zone, or treat 2 local zones with 5.0 ml each. The preparatory stage procedures are done once a week, but do not forget about sports and diet. Believe me, after 2-3 such procedures of lymphatic drainage vascular injection, even without the use of lipolytics, you will already notice positive changes. Below you can see an example of performing a lymphatic drainage vascular injection on the back (video 1) + working with local zones (video 2):

The third stage – tightening

As a rule, this stage takes 3 procedures - with an interval of 1 week between them. The task of this stage is to tighten the skin that has sagged a little after reducing the volume of fat deposits (24stoma.ru). Good express lifting can be achieved using preparations with 3% DMAE (for example, “Silor DM”). Additionally, you can use amino acids, peptides, and vitamins. Carrying out a main vascular puncture at this stage is carried out as desired and necessary.

Additionally, at this stage, to tighten the skin at home, you can use the DermaPen device, or a special mesoscooter for the body with a needle length of 2.5 mm. This will further increase the effect of injections of skin-tightening mesopreparations at the third stage.

Thus, the entire course lasts 12 procedures: at the first stage we do 3 procedures, at the second stage 6 procedures (more if necessary), + 3 procedures at the third stage. But as we said above, for very obese people 12 procedures will certainly not be enough, and people weighing more than 100 kg may require 3-4 times more procedures than in the standard lipocorrection course we described. For such patients, there is only the first stage, at which we perform only a main + local lymphatic drainage injection without the use of lipolytics - normally it should last from 5 to 10 procedures.

Effects of use

You can see the first changes after 1-2 mesotherapy sessions. Patients and cosmetologists note:

  • Restoration of facial oval, elimination of gravitational ptosis;
  • Disappearance of double chin, bags under the eyes;
  • Improvement of the relief of the cheeks, disappearance of puffiness;
  • Reduction in the volume of the abdomen, limbs, buttocks;
  • Disappearance of excess fat on the chest and shoulders, “widow’s hump”;
  • Reduction of signs of cellulite.

Lipolytic injections remove toxins and excess fluid from the body. The result depends on skin type, age, and severity of the problem.

Mesotherapy: cost of one procedure

For mesotherapy, the price of the procedure will depend on the volume and cost of the drugs administered, as well as on the pricing policy.
The cheapest price for injection mesotherapy services will be in a regular beauty salon, where they are provided by mesotherapists with secondary medical education. Prices will be higher in specialized dermatological clinics, where doctors with higher medical education usually conduct consultations. How much does body mesotherapy cost in specialized clinics for 2022: for example, in the price list you can see that the price of one procedure will be from 3,500 rubles (for 10.0 ml of the drug). Typically, 15.0 ml of the drug is prescribed for 1 body mesotherapy procedure for weight loss. Approximately 5.0 ml is used for the main vascular injection, and another 10.0 ml is used to work with local areas. Thus, the final price of 1 procedure in the clinic will be about 5,000-6,000 rubles, and the entire course of 12 procedures, for example, abdominal mesotherapy, can cost from 60,000 rubles.

But if you go to a mesotherapist at a beauty salon, then the prices in these establishments will be lower, and 1 procedure will cost from 2500 to 3500 rubles (depending on the drugs used). But these prices are true only for cellulite therapy and weight loss procedures, i.e. when working with the body. If we are talking about mesotherapy of the face, neck, scalp, as well as intensive facial biorevitalization procedures, the cost of the procedures will be different (see links below).

→ Cost of facial mesotherapy procedures → Cost of biorevitalization procedures → Cost of hair mesotherapy procedures

Mesotherapy: before and after photos

In this section you can see examples of what results can be achieved through injection mesotherapy. Moreover, please note that injections of mesopreparations are used not only to correct local fat deposits, but are also one of the main methods of treating cellulite (in the photo below, note the change in skin condition in patients with cellulite).

Mesotherapy procedures: before and after photos

Complications of lipolytic administration -

Local complications when working with the aggressive lipolytic deoxycholate are the formation of dense infiltrates and local fibrous compactions in the soft tissues. You should take into account that the more often you do courses of body mesotherapy for weight loss with deoxycholate, the more areas of fibrosis there will be in the fatty tissue. In turn, fibrosis of the pancreas will reduce the effectiveness of all subsequent courses of lipolytics, and without a cannula in the future it will be much more difficult to achieve a good effect.

If there are errors in calculating the volume of the drug and the depth of administration, very severe inflammatory reactions can occur. In addition, on the thighs or any areas with not too thick adipose tissue, the administration of deoxycholate can lead to a “washboard” effect. Those. There will be a focal decrease in the amount of fat with a change in the relief of the skin surface. Therefore, the safest local areas for administering deoxycholate are the stomach and sides.

You will also certainly have hematomas after injections (this always happens), and also a complication can also be understood as the lack of effect from the course of treatment. Considering all of the above, it is very important to understand which specialist you are seeing and what this specialist has the right to do for you.

An important question: which specialists have the right to perform lipolytic injections?

First of all, you should first make sure that the specialist you are visiting has the right to practice mesotherapy. It is good if mesotherapy is performed by a doctor, i.e. specialist with higher medical education. But in most cases, nurses work as mesotherapists. In order for a nurse to receive the right to practice mesotherapy, she must complete the following two training courses for advanced training - 1) “nursing in cosmetology”, 2) a training course in mesotherapy.

Let me draw your attention to the fact that the right to practice mesotherapy does not appear after any training course in mesotherapy, but only if it is a standardized course that complies with the program approved by the Ministry of Education. Such a course must last at least 32 hours, and after its completion, a certificate of an established (state) standard is issued on paper with watermarks (Fig. 17). All other courses and certificates do not give the right to engage in this type of activity.

What should a standard mesotherapy certificate look like?

In addition, there is also such a profession as “cosmetologist-esthetician,” which means that such a specialist can only give you facial massage, masks and peelings. That is, this is not even a health worker at all. However, in an effort to earn money, many training centers teach mesotherapy even to such “specialists” who do not even have a secondary medical education (thus violating the law). Therefore, you should make sure that you are at least not a cosmetologist-esthetician when doing lipolytic injections.

Separately, it is worth mentioning the administration of lipolytics by cannulas. This is a more complex technique, and mesotherapists with secondary medical education do not have the right to do this; they can only administer lipolytics by injection. Only doctors can legally work with cannulas, i.e. specialists with higher medical education (cosmetologists, surgeons).

How do direct lipolytics work?

Direct lipolytics directly affect adipose tissue. Unlike indirect ones, they destroy adipocyte membranes and dissolve the internal contents of cells. This leads to a rapid reduction in the volume of the treated area.

Injections of these drugs are considered the most effective alternative to surgical liposuction. Direct lipolytics remove fat in areas that cannot be modeled by diet and physical training.

Injections of meso-cocktails for weight loss are made under the skin to a depth of 1 cm.

The drugs are sold in specialized pharmacies and on manufacturers' websites. The procedure requires special training and experience from the doctor. Failure to comply with the technique and dosages can lead to serious complications.

A few words about hormones and nutrition -

Lipogenesis (the process of accumulation of fatty acids in fat cells) is triggered by the hormone known to you as insulin. The higher its concentration in the blood, the more fat cells capture fatty acids, accumulating them. And if you want to reduce the volume of adipose tissue, then it is important not only to inject lipolytics, but first you should exclude foods with a high glycemic index (boiled potatoes and carrots, rice, starch, sugar, etc.) from your diet.

Secondly, diet is important, i.e. It is best to eat more often, but little by little. This allows you to reduce peak insulin concentrations in the blood and also make your metabolism more intense. Thirdly, good sleep is important. If you don’t get enough sleep, the body’s production of growth hormone decreases, and this hormone is one of the activators of lipolysis. As a result, poor sleep also contributes to weight gain. We hope you found this article useful!

Sources:

1. Add. professional


, 2. Personal experience with clinical use, 3. National Library of Medicine (USA), 4. The National Center for Biotechnology Information (USA), 5. “Aesthetic mesotherapy” (Tochinova N.A.), 6. https://www.mesopharm.ru/.

How do lipolytics work?

The name of the group of drugs “lipolitics” literally means “fat breakers”. They were created as a medicine to eliminate cholesterol plaques. Later, testers recorded a fat-burning effect. Now these products are widely used in cosmetology practice.

Lipolitics will not help you lose significant weight. They are used to combat small accumulations of fat in certain areas of the body and correct the figure. In 1 session you can reduce your waist or hips by 2-3 cm. This is approximately 100 ml of adipose tissue.

The advantages of lipolytics include:

  • Rapid onset of effect;
  • Ability to accurately model small areas of the body;
  • Getting rid of cellulite;
  • Lack of special training and simple rehabilitation.

Disadvantages include painful insertion. The drugs are used in the form of injections. Using a thin needle, the solution is injected under the skin to a depth of 1 cm.

All lipolytics are divided into 2 groups - direct and indirect. They differ in composition and mechanism of action.

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