The original drug Skin-cap or an analogue: what are their differences?

Compound

Is it possible to replace the original drug Skin-cap with an analogue?

In theory, generics are developed precisely to provide consumers with as much choice as possible. Due to the relative cheapness of such products, ordinary people often prefer generics to original drugs. On the one hand, “substitutes” also provide a certain effect in the treatment of diseases. But at the same time, even a doctor cannot always predict the effectiveness of an analogue in comparison with the original drug.

Taking all this into account, it is necessary to clearly understand that the prescription of any treatment, including the use of generics, lies solely within the competence of the doctor.

But often a doctor finds himself in a situation where, having prescribed the original drug Skin-Cap to a patient, his recommendations at the pharmacy are replaced by a pharmacist, offering a cheaper drug (analog) or a cosmetic care product with zinc pyrithione, which cannot have a therapeutic effect. The patient was treated, but did not get the desired effect and returns to the doctor with a complaint. That is why doctors often recommend a specific trade name when prescribing an original drug.

Pharmacodynamics

Activated zinc pyrithione has anti-inflammatory, antibacterial and antifungal activity. Antifungal activity is especially pronounced against Pityrosporum ovale and Pityrosporum orbiculare, which support inflammation and excessive flaking in dandruff, seborrhea, psoriasis and other skin diseases.

The antibacterial activity of zinc pyrithione is manifested against a number of pathogenic microorganisms (including streptococcus, staphylococcus, Pseudomonas aeruginosa and Escherichia coli, Proteus).

Zinc pyrithione reduces the intracellular level of ATP, promotes depolarization of cell membranes and the death of fungi and bacteria.

The mechanism of anti-inflammatory action has not been studied.

The production of original medicines is a constant investment

The work scenario of a pharmaceutical company that develops and produces original drugs is quite classic. The company is conducting a series of developments, testing various combinations of components, and synthesizing certain substances that help solve certain health problems. When the drug has been studied from all sides, it will be put into mass production and sales through pharmacies and pharmacy chains.

At first glance, the described process is very simple. But in reality everything is more complicated. To bring a new drug or active substance to market, it can take years or even decades for a pharmaceutical company. The development of new medicines involves a whole series of tests and trials. And you need to be prepared for the fact that some of them will lead to zero or negative results, then all processes will need to be started again. In general, the development, research, organization and conduct of clinical trials, as well as the resolution of related issues (licensing, certification, etc.) require the manufacturer not only years of work, but also impressive sums.

If we consider the original drug Skin-cap and its analogues, then when the drug Skin-cap was first released onto the market, the following steps were followed:

• Laboratory research. At this stage, the active substance has been tested in laboratory conditions. The research department studied the mechanisms and features of pathological processes in the skin in psoriasis, atypical and seborrheic dermatitis, and identified possible points of application of the drug. Based on the data obtained, experts selected an active substance that, theoretically and practically, can have a clinical effect.
• Preclinical trials. In this case, we are talking about the fact that the selected active substance was first studied using a laboratory model, which helps to determine the mechanisms of action of the active substance on the pathological process.
• Clinical trials are studies on volunteers that allow us to prove the effectiveness and safety of zinc pyrithione activated as part of Skin-cap in various groups of patients. All this makes it possible to determine the optimal dosage of the drug and identify the most common side effects.

But even after the release of the original drug Skin-cap on the market, the manufacturing company continues to confirm the effectiveness and safety of the drug by conducting studies in real clinical practice on large groups of patients. The most powerful studies are those with placebo control. Unlike analogs, the drug Skin-cap has such studies, and the total evidence base of the drug is about 50 studies that were conducted in leading clinical centers in Russia for various skin diseases. Thanks to such a strong evidence base, Skin-cap is included in current clinical recommendations for the treatment of psoriasis, atopic and seborrheic dermatitis.

Directions for use and doses

Externally.

Aerosol: spray onto the affected areas of the skin from a distance of 15 cm 2-3 times a day until a clinical effect is achieved. To achieve a lasting effect, it is recommended to continue using the drug for 1 week after the symptoms disappear. To treat the scalp with the drug, a special nozzle is included. The course of treatment for psoriasis is 1-1.5 months, for atopic dermatitis - 3-4 weeks.

The method of administration and dosage for children do not differ from those for adults.

If necessary, you can repeat the course of treatment after 1–1.5 months, after consultation with your doctor.

Cream: after vigorous shaking, apply a thin layer to the affected areas of the skin 2 times a day. The course of treatment for psoriasis is 1-1.5 months, for atopic dermatitis - 3-4 weeks.

The method of administration and dosage for children do not differ from those for adults.

If necessary, you can repeat the course of treatment after 1–1.5 months, after consultation with your doctor.

Shampoo: before use, shake the bottle vigorously, apply a small amount of shampoo to damp hair and massage the scalp, then rinse your hair and reapply shampoo. Leave the shampoo on your hair for 5 minutes and rinse thoroughly with plenty of water. Use 2-3 times a week for the first 2 weeks. The course of treatment for psoriasis is 5 weeks, for seborrhea - 2 weeks.

During the period of remission, shampoo can be used 1-2 times a week as a means of preventing relapses.

Why are analogues and original drugs not the same thing?

Patients often hear from a dermatologist that the clinical results from using the drug Skin-cap and its analogue are different.

You should not assume that the original drug Skin-cap and its analogues are equivalent in effectiveness.

In fact, manufacturers of analogues are required to use the same active substance in their products as in the original drug. Generics themselves must meet several criteria:

• produced in the same form as the original (that is, it can be a cream, aerosol, shampoo);
• have a similar pharmacological effect, that is, the ability to be used to treat the same diseases.

Thus, the instructions for the original drug Skin-cap and its analogue will be practically indistinguishable.

The analogue, like the original drug Skin-cap, also undergoes certain tests. However, we are not talking about conducting full-fledged preclinical and clinical trials in the usual sense. The task is to prove the comparability with the original molecule and the safety of your product.

As for clinical studies, analogues of the drug Skin-cap often use the results obtained in studies using the original drug, and, as a rule, have only 1-2 of their own studies, which are often conducted without placebo control.

Due to all these factors, the production of generics is significantly reduced in cost. However, it is incorrect to talk about their complete equivalence with original drugs.

If you are trying to figure out how a generic drug differs from an original drug, you should not forget about such a thing as production standards. Different countries set their own quality criteria for the production of “substitutes” for medicines.

In order to minimize costs, analogue manufacturing companies often choose cheaper production lines, but at the same time invest in advertising promotion. The original Skin-cap is produced in Europe (Spain/France) in accordance with national and international quality standards.

Release form

Aerosol for external use, 0.2%. 35, 70, 140 g of the drug in an aluminum aerosol can, which consists of a valve and a cap. The cylinder along with an additional nozzle is placed in a cardboard box.

35 g of the drug in an aluminum aerosol can, which consists of a valve and a cap (free sample).

Cream for external use, 0.2%. 5 g in a sachet made of laminated foil. 15 and 50 g in a plastic tube. Each tube is placed in a cardboard box

Shampoo, 1%. 50 ml, 150 ml, 400 ml in a plastic bottle. Each bottle is placed in a cardboard pack. 5 g in a sachet made of laminated foil. 5 sachets are placed together in a cardboard pack. 5 g in laminated foil sachets (free sample).

Why are generics so much inferior to original drugs?

There are several objective reasons why the analogues and the original drug Skin-cap cannot be considered completely identical. The main difference comes down not only to the difference in the auxiliary components in the “substitutes”. There are other, no less significant factors.

Feedstock for production

The requirement to use a similar active substance in generics is strictly fulfilled by manufacturers. However, they select suppliers at their own discretion and use other methods of obtaining raw materials. Differences in technology can produce completely different end results. The main danger lies in the fact that generics often use raw materials with a low degree of purification.

List of auxiliary components

It may seem that the presence of additional components in generics does not play any role. Manufacturers often insist that by adding new ingredients (for example, panthenol), the formula becomes even more effective, safer, better quality, etc. In fact, this is nothing more than a classic marketing ploy.

Adding auxiliary components, at best, does not carry any meaning, since in most situations the additives used are either not perceived by the body or do not have the desired effect due to their low concentration. And in the worst case, it can affect the effect of the active substance by changing its interaction with the skin.

How to distinguish an original drug from a generic?

There are several key aspects that can help you figure out which drug is in front of you.

1. Duration of circulation of the drug on the market. The original drug Skin-cap has been circulating on the Russian market for more than 25 years, but analogues come out much later (after 10-15 years).
2. Price. The price of a medicine is a fundamental factor by which one can distinguish the original sample from the “substitute”. Because production costs for generic drugs are significantly reduced, they usually cost less at retail. Sometimes the price difference is three to four times.
3. Package. The manufacturer of the original drug Skin-cap has invested a lot of money in the development of packaging. It is well recognizable and made of high quality material. For example, the ergonomic packaging of Skin-cap cream ensures economical consumption due to its narrow neck, the cream closes “up to the cheek”, and the lid itself is non-removable, which protects the drug from accidental consumption and contamination.

Features and composition of Skin Cap shampoo

One of the most common problems is dandruff, as every third person suffers from this disease. No person of any gender or age is immune from its occurrence. There are many reasons for the appearance of seborrhea. More often, its occurrence is caused by disruption of the sebaceous glands, the development of pathogenic microflora, stress, and poor nutrition.

The occurrence of seborrhea leads to the appearance of irritation, itching, and white flakes. All this requires timely treatment. Special products produced by various pharmacological and cosmetology companies can help eliminate the problem.

One of these drugs is Skin Cap anti-dandruff shampoo. It has proven its effectiveness in clinical studies. Therefore, it is often prescribed for a variety of dermatological diseases.

The product has pronounced antifungal and antibacterial properties. Externally it is a white suspension without a pungent odor.

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Reference. Skin Cap shampoo is intended for external use only and is used for the treatment of skin diseases in adults and children over one year of age (only for the treatment of psoriasis).

The main active ingredient of the drug is zinc pyrithione. Zinc is often used to combat a variety of skin diseases. It helps fight pathogenic microorganisms, relieves inflammation, skin irritation, and eliminates itching. In addition, the substance helps reduce the production of subcutaneous sebum and eliminates peeling of the epidermis.

Skin Cap also contains various excipients and coconut oil extract.

With regular use of shampoo:

1. The amount of dandruff is reduced. The effect is noticeable after the first use.
2. Eliminates irritation and itching.
3. Pathogenic microflora and fungi die.
4. Hair is saturated with nutrients and is carefully cared for.
5. Sodium lauryl sulfate fights excess oil, slightly drying the epidermis.
6. The shampoo deeply but gently cleanses hair of dust, dirt, and styling products.

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The drug contains methyl ethyl sulfate. It promotes rapid penetration of nutrients into the epidermis. Thanks to this, the healing effect of zinc pyrithione is enhanced.

Reference. Skin Cap shampoo does not have a negative effect on the original hair color. Moreover, during the treatment period it is recommended to additionally use auxiliary cosmetic preparations: balms, masks, emulsions, oils, sprays and others.

It is worth mentioning the advantages and disadvantages of the drug.

So, the advantages include:

• proven effectiveness;
• safety for the epidermis, hair cuticle;
• ease of use;
• the property of accumulating the effect, which ensures a long-lasting beneficial effect and a long stage of remission;
• pleasant unobtrusive scent with notes of citrus.

Skin Cap shampoo can be purchased at any pharmacy.

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The disadvantages are:

1. Possibility of an allergic reaction with frequent use.
2. Like any medicinal drug, shampoo has contraindications for use. Thus, it is not recommended for persons under 18 years of age. An exception is the treatment of psoriasis in children. It is also prohibited for use by people with individual intolerance to the components of the drug.
3. High price. The price of shampoo exceeds one thousand rubles.

Important! Before use, it is necessary to test for an allergic reaction. To do this, apply a small amount of shampoo to the crook of your elbow or wrist and leave for a few minutes. Then you should evaluate the reaction. If itching or irritation occurs, do not use shampoo.

To achieve the desired effect, the drug must be used 1-2 times a week. The course of therapy for dandruff takes at least two weeks, for the treatment of psoriasis - five.

Attention! Avoid contact of the product with the mucous membranes of the eyes. This can lead to the development of cataracts and glaucoma.

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Analogues of Skin Cap shampoo

If the drug is not suitable for individual indicators or you are confused by its cost, then you should pay attention to existing analogues:

1. "Zinocap." The product is available in the form of a cream or spray, so it is convenient to use. The composition also includes zinc pyrithione. The drug has no contraindications and works well against itching and flaking. Promotes the death of pathogenic microorganisms.

2. Friederm Zinc. Has a similar effect. It will help in the fight against seborrhea, psoriasis, atopic dermatitis and other skin diseases.

3. "Pyrithione Zinc". It has an identical composition, therefore it has a similar effect. It has a more affordable price.

When treating skin diseases, it is necessary to take into account that it will be more effective in complex therapy. Therefore, it should be supplemented with proper nutrition, high-quality care for the scalp and hair. Do not forget about taking vitamin and mineral complexes. You should also consult a trichologist or dermatologist and strictly follow the instructions in the instructions.

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