Efficacy and safety of long-term use of the drug Diane-35 for the treatment of androgenization symptoms

Acne (pimples) often occurs due to dysfunction of the sweat and sebaceous glands, which are located in the upper layers of the epidermis.

Usually the appearance of acne indicates diseases of the body, most often this is how problems with the endocrine system manifest themselves.

In cases where external medications to combat acne do not help or their effects are weak, then the dermatologist prescribes a hormonal examination and, based on the tests, prescribes the drug Diane 35.

Indications

The drug is prescribed only to girls and women.
The main reason for prescribing this particular drug is hormonal imbalance , when the content of hormones, in particular the androgynous group, affects the disturbance of fat metabolism in the body. As a result, sebum production increases and sweating increases.

These factors lead to clogging of pores and the proliferation of bacteria, which provoke the appearance of pimples and blackheads, which can be difficult to treat.

Often the problem manifests itself in adolescence and persists after puberty, worsening depending on the phase of the menstrual cycle.

Composition and properties

The use of “Diane 35” in the fight against acne is possible only when the root cause of its appearance is a hormonal imbalance.

The main component of the drug is cyproterone acetate. Helps slow down the production of male hormone (androgen) in the female body. This helps against acne, because the glands do not secrete secretions in large quantities, which affects the appearance of acne, acne, and ulcers.

3-4 months after starting to take the drug, you can notice changes in the body. The condition of the dermis improves, the hair becomes thicker, falls out less, and the oiliness of the scalp decreases. Acne and rashes disappear. The menstrual cycle improves, as the drug helps restore hormonal levels in girls and women. The pharmaceutical product reduces sebum production and stops the development of bacteria that appear when pores are clogged or contaminated.

Why does Diana 35 help with acne?

The composition of the drug Diane 35 includes cyproterone acetate , which reduces the production of androgens (male sex hormones), they are produced in excess in the female body.
That is why it becomes possible to treat acne and acne that appear against the background of an imbalance of this group of hormones.

While taking the drug, the level of excess hormones decreases, the hyperfunction of the sebaceous glands, which affects the occurrence of pimples, blackheads and seborrhea, weakens.

After a few months (3-4) of taking the drug, the condition improves, while at the same time the oiliness of the hair and its loss decrease, and hirsutism also manifests itself less .

Many oral contraceptives of the combined group have this effect, but in the case of Diane 35 the effect is more pronounced. In parallel with this, the menstrual cycle is adjusted, and pain during menstruation is reduced.

Most often, this therapeutic effect manifests itself in women from 20 to 40 years old, because acne is not only a teenage problem , women of childbearing age often face it; on average, 40% of the fair sex have a problem with acne, which Diane 35 helps treat.

After completing a course of treatment with this drug, most patients note the complete disappearance of acne. Therefore, if your tests show an increased level of male hormones, then Diane 35 will help solve the problem by restoring the body’s hormonal levels.

Effective fight against acne is possible only with complex treatment. When using preparations for internal use, do not forget about cosmetic skin treatment.

We recommend that you pay attention to the amazing properties of tea tree oil, from which you can prepare various masks, scrubs and other acne remedies at home.

Side effects from using Diane-35 for the treatment of pimples and acne

"Diane-35" is a hormonal drug, so all aggravating phenomena will be of a corresponding nature.

Regardless of the main purpose of use - it will be protection from unwanted pregnancy or treatment of skin rashes - the threat of deterioration of health is present. This applies to the body of even absolutely healthy women. When the concentration of hormones in the blood increases sharply, one should expect problems with the functional ability of internal organs, mental state, which will affect lifestyle or create the need to change the daily routine.

Common side effects from taking Diane-35:

1. Frequently recurring episodes of headache. 2. A feeling of heaviness in the parietal region and the back of the head, pulsation in the temples. 3. Dizziness. 4. Increased sensitivity of the mammary glands, swelling of the breasts, pain in the nipples. 5. The appearance of discharge from the mammary glands - the consistency of the secretion resembles colostrum, which is produced in the first trimester of pregnancy. 6. Weakening libido. 7. Feeling of constant fatigue, desire to rest more. 8. Instability of the psycho-emotional background, sudden mood swings. 9. Difficulties arise with the use of contact lenses - the mucous membrane of the eyes rejects this device, causing lacrimation and conjunctivitis. 10. Dyspeptic disorders develop - the woman feels sick, sometimes the attack ends with vomiting. 11. Vaginal discharge takes on a different character. 12. Additional skin inflammations appear. 13. A woman experiences peripheral edema - this phenomenon must be coupled with difficulties in the functioning of the kidneys. 14. The outflow of urine is delayed. 15. The sense of smell is heightened, the condition resembles a period of toxicosis, when primitive smells irritate and cause disgust. 16. Body weight is gained by at least 10%.

It is impossible to predict what reaction the body will have to taking the Diane-35 contraceptive, so before using the pills, you need to determine the state of your hormonal levels. Knowing the indicators of the hormonal panel, you can be sure that treating acne with this particular contraceptive is at least advisable. And most importantly, it will not harm the woman’s health. During treatment with Diane-35, you should not squeeze out the rash that appears or otherwise try to speed up the healing process of wounds if acne leads to them. The drug helps get rid of acne on the body, but does not eliminate blue spots and scars that remain after mechanical action on inflammatory elements.

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How to take Diana 35 correctly?

Before you start taking the drug, you must undergo a complete gynecological examination in order to identify problems with your health and hormone levels.
When treatment with this particular drug is indicated, only a doctor can prescribe treatment.

When you see your doctor, be sure to tell him if you have any of the following problems:

• systematic smoking;
• diabetes mellitus in you or in your immediate family;
• excess weight;
• problems with blood pressure, heart or circulatory system;
• migraines and epilepsy;
• breast cancer in you and your immediate family;
• diseases of the liver, intestines, skin, blood;
• presence of holoasma (brown pigmentation on the skin).

If at least one of the problems has manifested itself before or appears while taking the drug, then you must inform your doctor about it, because the effectiveness of acne treatment and your health in the future depends on this.

Directions for use and doses

The drug must be taken regularly in order for the full therapeutic effect to be achieved.
The package contains 21 tablets. In the package, the pills are marked according to the day of the cycle (week) when it should be taken.

You need to take the drug in accordance with the marked day at the same time ; for simplicity, the direction of administration is also indicated by arrows. After 21 days, you must take a break in order for menstruation to begin, and after the break, the drug is taken again according to the same regimen.

The first package of Diane 35 should be taken on the first day of the monthly cycle, in full accordance with the day labeling; if, for example, bleeding began on Wednesday, then you should take a pill labeled “Wednesday”.

If you combine acne treatment with contraception, then for the first 3-5 days you need to additionally use barrier methods of contraception.

To achieve a therapeutic effect, the drug is used for at least 4-6 months . Often, the doctor prescribes a course of treatment in accordance with the test results and may note the intake as you recover; in case of relapse, the drug Diane 35 may again be prescribed, which will be taken according to the previously described regimen.

If you use other oral contraceptives, your doctor will advise you on the procedure for changing the drug to obtain the therapeutic effect of Diane 35.

It is impossible to take two different hormonal contraceptives at the same time, due to the fact that this is dangerous to life and health.

Instructions for use DIANE®-35 (DIANE-35)

For oral administration.

Taking Diane-35 should be regular to achieve the necessary therapeutic effectiveness and contraceptive effect. Previously used hormonal contraceptives should be discontinued. The dosage regimen for Diane-35 is similar to that for most other combined oral contraceptives, so general guidelines for use must be taken into account. When taken correctly and regularly, combined oral contraceptives have high contraceptive reliability, with a “method failure” rate of no more than 1% per year. Irregular use of Diane-35 can lead to intermenstrual bleeding and worsen the therapeutic and contraceptive effectiveness of the drug.

The pills should be taken in the order indicated on the package, every day at approximately the same time, with a small amount of water. Take one tablet per day continuously for 21 days. Each subsequent package begins after a 7-day break, during which withdrawal bleeding (menstrual-like bleeding) is observed. It usually begins 2-3 days after taking the last pill and may not end until you start taking a new package.

How to start taking Diane-35

- in the absence of taking any hormonal contraceptives in the previous month.

Taking Diane-35 begins on the first day of the menstrual cycle (i.e., on the first day of menstrual bleeding). It is allowed to start taking it on days 2-5 of the menstrual cycle, but in this case it is recommended to additionally use a barrier method of contraception during the first 7 days of taking the pills from the first package.

- when switching from combined hormonal contraceptives (combined oral contraceptive, vaginal ring, transdermal patch).

It is preferable to start taking Diane-35 the day after taking the last hormone-containing pill from the previous package, but in no case later than the next day after the usual 7-day break in taking (for drugs containing 21 pills) or after taking the last hormone-free pill (for preparations containing 28 tablets per package). When switching from a vaginal ring or transdermal patch, it is preferable to start taking Diane-35 on the day the ring or patch is removed, but in no case later than the day when the next ring or patch was to be applied.

- when switching from contraceptives containing only gestagens (mini-pills, injectable forms, implant), or a gestagen-releasing intrauterine device (IUD).

A woman can switch from the mini-pill to Diana-35 on any day (without a break), from an implant or IUD with progestogen - on the day of its removal, from the injection form - from the day when the next injection would have been given. In all cases, it is necessary to use an additional barrier method of contraception during the first 7 days of taking the pill.

- after an abortion in the first trimester of pregnancy.

A woman can start taking the drug immediately. If this condition is met, the woman does not need additional contraceptive protection.

- after childbirth or abortion in the second trimester of pregnancy.

A woman should be advised to start taking the drug 21-28 days after childbirth or abortion in the second trimester of pregnancy. If use is started later, it is necessary to use an additional barrier method of contraception during the first 7 days of taking the pill. However, if a woman has already been sexually active, pregnancy should be excluded before starting Diane-35 or she must wait until her first menstruation.

Taking missed pills

If the delay in taking the pill is less than 12 hours, contraceptive protection is not reduced. A woman should take the pill as soon as possible, and the next pill should be taken at the usual time.

If the delay in taking the pill is more than 12 hours, contraceptive protection may be reduced. In this case, you can be guided by the following two basic rules:

• Taking the pills should never be interrupted for more than 7 days.
• 7 days of continuous administration of the pills are required to achieve adequate suppression of the hypothalamic-pituitary-ovarian system. Accordingly, the following advice can be given if the delay in taking the pill is more than 12 hours (the interval since the last pill was taken is more than 36 hours):

- first week of taking the drug.

A woman should take the last pill she missed as soon as she remembers (even if this means taking two pills at the same time). The next pill is taken at the usual time. Additionally, a barrier method of contraception (for example, a condom) should be used for the next 7 days. If sexual intercourse took place during the week before missing the pills, the possibility of pregnancy must be taken into account.

The more tablets are missed, and the closer they are to a break in taking active substances, the greater the likelihood of pregnancy.

- second week of taking the drug.

A woman should take the last pill she missed as soon as she remembers (even if this means taking two pills at the same time). The next pill is taken at the usual time. Provided that the woman took the pill correctly during the 7 days preceding the first missed pill, there is no need to use additional contraceptive measures. Otherwise, as well as if you miss two or more pills, you must additionally use barrier methods of contraception (for example, a condom) for 7 days.

- third week of taking the drug.

The risk of decreased reliability is inevitable due to the upcoming break in taking the pill.

A woman must strictly adhere to one of the following two options. Moreover, if in the 7 days preceding the first missed pill, all pills were taken correctly, there is no need to use additional contraceptive methods.

1. The woman should take the last missed pill as soon as possible (even if this means taking two pills at the same time). The next pill is taken at the usual time, until the pills from the current package run out. The next pack should be started immediately. Withdrawal bleeding is unlikely until the second pack is finished, but spotting or breakthrough bleeding may occur while taking the pill.

2. A woman can also stop taking pills from the current package. She should then take a break for 7 days, including the day she missed the pills, and then start taking a new pack.

If a woman misses taking the pill and then does not have withdrawal bleeding during the break from taking the pill, pregnancy must be ruled out.

Tips for gastrointestinal disorders

In severe gastrointestinal disorders, absorption of the drug may be incomplete. In this case, additional contraceptive measures should be taken.

If a woman vomits within 3-4 hours after taking Diane-35 tablets, you should follow the advice regarding skipping the tablets. If a woman does not want to change the normal regimen of taking the drug, she should take, if necessary, an additional tablet (or several tablets) from another package.

Duration of use

For the purpose of contraception, the drug is taken for a long time.

When treating hyperandrogenic conditions, the duration of use is determined by the severity of the disease and the effectiveness of treatment. As a rule, treatment should be carried out over several months. When treating acne and seborrhea, the effect usually occurs earlier than when treating hirsutism or alopecia.

After the symptoms disappear, it is recommended to take Diane-35 for at least another 3-4 months. If a relapse occurs several weeks or months after completion of the course, Diane-35 can be re-treated. In this case, the possibility of early resumption of Diane-35 therapy should be considered.

Changing the start day of the menstrual cycle

In order to delay the onset of menstruation, a woman should continue taking pills from the new Diane-35 package immediately after all the pills from the previous one have been taken, without interruption. The pills from this new package can be taken for as long as the woman wishes (until the package runs out). While taking the drug from the second package, a woman may experience spotting or breakthrough uterine bleeding. You should resume taking Diane-35 from a new package after the usual 7-day break.

In order to postpone the start of menstruation to another day of the week, a woman should shorten the next break in taking the pills by as many days as she wants. The shorter the interval, the higher the risk that she will not have withdrawal bleeding and, in the future, will have spotting and breakthrough bleeding while taking the second package (the same as in the case when she would like to delay the onset of menstruation).

Additional information for special categories of patients

Children and teenagers.

The drug Diane-35 is indicated only after the onset of menarche.

Elderly patients.

Not applicable. The drug Diane-35 is not indicated for women after menopause.

Patients with liver disorders.

Diane-35 is contraindicated in women with severe liver disease until liver function tests return to normal.

Patients with kidney disorders.

Diane-35 has not been specifically studied in patients with renal impairment. Available data do not suggest changes in treatment in these patients.

Contraindications for taking this drug

There are the following contraindications for using the drug:

• thrombosis, acute or already treated;
• cardiovascular diseases, heart attacks, angina pectoris, strokes, both acute and already treated;
• diabetes mellitus of both types with vascular disorders;
• diseases of the liver, gall bladder, hepatitis, cancer of the liver;
• oncological diseases of the mammary glands, genital organs, acute or in remission;
• uterine bleeding, the causes of which have not been determined;
• pregnancy, lactation;
• the presence of allergic reactions to the components of the drug.

At the first manifestations of illness or side effects, immediately stop taking the drug and consult a doctor to prescribe other treatment.

Remember that taking Diane 35 does not protect against HIV infection or sexually transmitted infections. Never offer the drug to other people if it was prescribed to you.

If you are pregnant, taking the drug may cause a miscarriage or the development of abnormalities in the fetus.
During lactation, taking the drug is prohibited due to the fact that loss of the ability to produce milk may occur, and the risk of mastopathy increases. Separately , it should be noted that the drug is not prescribed for children and adolescents, and it is also contraindicated after menopause.
Women with liver disease should not take the drug until clinical liver parameters return to normal. For women with kidney problems, the drug is most often not prescribed due to the fact that the effect of the drug has not been fully studied, and it is not known how the kidneys will react to it. For those women who smoke, the drug is not prescribed ; the combination of nicotine and medicinal components of Diane 35 can lead to the development of serious consequences, such as thrombosis or stroke.

Acne sulfur is one of the most popular cosmetic products. It has a mild bactericidal effect, which is why it is included in many medications.

Contraindications and side effects

While using the medication, adverse reactions may occur in the form of mood swings or drowsiness.
Most medications have consequences, and so it is with Diana 35:

• gaining excess weight or, conversely, losing weight;
• rash on the skin;
• swelling;
• delayed excretion of water from the body;
• drowsiness;
• mood swings;
• headache;
• nausea and vomiting;
• sensitivity to odors;
• dizziness;
• change in discharge.

This drug has the following contraindications:

• uterine bleeding;
• period of pregnancy and lactation;
• diabetes;
• cardiovascular pathologies;
• heart attack;
• oncological diseases;
• hepatitis;
• allergic reaction to the medicine.

The remedy is not prescribed to children, adolescents and after menopause, if acne is not caused by changes in hormonal levels. The drug is contraindicated for women who smoke. Use while smoking can cause thrombosis and stroke. If side effects are noticed, you should consult a doctor. The medicine is prescribed individually. It should be remembered that the cost of the drug is not low, and the course of treatment can be long. You cannot suddenly stop taking Diane 35 tablets.

Side effects caused by taking Diane 35

Tell your doctor immediately if you notice changes in your health that you have not previously experienced or that are associated with other medical conditions.

Side effects include:

• headaches, dizziness;
• engorgement, pain and fluid discharge from the mammary gland;
• libido disturbance;
• mood swings or loss of energy;
• development of intolerance to contact lenses;
• nausea or vomiting;
• changes in vaginal discharge;
• skin rashes that have not previously been observed;
• swelling and retention of urine;
• changes in body weight, both its increase and decrease;
• manifestation of hypersensitivity reactions to odors.