Belosalik 15g ointment for external use

Compound

Pharmacodynamics

Belosalik®lotion has anti-inflammatory, antipruritic, anti-edematous, antiallergic, antiproliferative, immunosuppressive, keratolytic, antimicrobial and antifungal effects.

Betamethasone dipropionate is a synthetic corticosteroid that has anti-inflammatory, antiallergic, antipruritic and vasoconstrictor effects. When applied to the surface of the skin, it constricts blood vessels, relieves itching, reduces the release of inflammatory mediators (from eosinophils and mast cells), IL-1 and -2, interferon gamma (from lymphocytes and macrophages), inhibits the activity of hyaluronidase and reduces the permeability of the vascular wall. Interacts with specific receptors in the cytoplasm of the cell, stimulates the synthesis of mRNA, inducing the formation of proteins, incl. lipocortin, mediating cellular effects. Lipocortin inhibits phospholipase A2, blocks the release of arachidonic acid and the biosynthesis of endoperoxides, PGs, and leukotrienes (which contribute to the development of inflammation, allergies and other pathological processes).

Salicylic acid, due to its keratolytic action, cleanses affected areas of scales, promotes the penetration of betamethasone into the skin, maintains the acidic environment of the skin, preventing the development of bacterial and fungal infections.

Belosalik 15g ointment for external use

pharmachologic effect

Glucocorticosteroid for local use + keratolytic agent.

Composition and release form Belosalik 15g ointment for external use

1 g of ointment for external use contains:

• active ingredients: betamethasone (in the form of dipropionate) - 0.640 mg, which corresponds to 0.500 mg of betamethasone, salicylic acid - 30 mg;
• excipients: mineral oil – 100 mg, petroleum jelly – 869.36 mg.

Ointment for external use.

10g, 15g, 20g, 30g and 40g in aluminum tubes. The tube opening is protected by a membrane. The tube is closed with a plastic cap with a cut and a punch. 1 tube of 10g, 20g and 40g along with instructions for use is placed in a cardboard box. 1 or 2 tubes of 15g and 30g along with instructions for use are placed in a cardboard box

Description of the dosage form

White, translucent, homogeneous ointment.

Directions for use and doses

Externally.

BELOSALIK® in the form of an ointment for external use is intended for use on smooth skin.

BELOSALIK® ointment is used twice a day. A small amount of ointment is evenly distributed over the surface of the skin, lightly rubbing. In mild cases, single use is sufficient.

The course of treatment is usually 3-4 weeks. If a longer course of therapy is necessary, it is recommended to use the drug less frequently, for example, every other day. When treating chronic diseases, treatment should be continued for some time after the disappearance of all symptoms under the supervision of a physician in order to avoid relapse of the disease. Therapy may be repeated several times throughout the year.

Pharmacodynamics

Belosalik® lotion has anti-inflammatory, antipruritic, anti-edematous, antiallergic, antiproliferative, immunosuppressive, keratolytic, antimicrobial, antifungal effects.

Betamethasone dipropionate is a synthetic glucocorticosteroid (GCS) that has anti-inflammatory, antiallergic, antipruritic and vasoconstrictor effects. When applied to the surface of the skin, it constricts blood vessels, relieves itching, reduces the release of inflammatory mediators (from eosinophils and mast cells), interleukins 1 and 2, interferon gamma (from lymphocytes and macrophages), inhibits the activity of hyaluronidase and reduces the permeability of the vascular wall. Interacts with specific receptors in the cytoplasm of the cell, stimulates the synthesis of mRNA, inducing the formation of proteins, including lipocortin, mediating cellular effects. Lipocortin inhibits phospholipase A2, blocks the release of arachidonic acid and the biosynthesis of endoperoxides, prostaglandins, leukotrienes (promoting the development of inflammation, allergies and other pathological processes).

Salicylic acid, due to its keratolytic action, cleanses affected areas of scales, promotes the penetration of betamethasone into the skin, maintains the acidic environment of the skin, preventing the development of bacterial and fungal infections.

Indications for use Belosalik 15g ointment for external use

BELOSALIK® is used for the treatment of subacute and chronic dermatoses, sensitive to external corticosteroid therapy, accompanied by hyperkeratosis and peeling.

Psoriasis, eczema (dyshidrotic, seborrheic, tylotic), neurodermatitis, lichen planus, chronic discoid lupus erythematosus, ichthyosis and ichthyotic skin lesions, etc.

Contraindications

Hypersensitivity to betamethasone, salicylic acid or any of the auxiliary components of the drug.

Skin tuberculosis, skin manifestations of syphilis, chicken pox, viral skin infections, skin post-vaccination reactions, open wounds, trophic ulcers, rosacea, acne vulgaris, children under 6 months of age.

CAREFULLY

Liver failure, childhood, long-term therapy, especially with the use of occlusive dressings.

Effect on the body

Glucocorticosteroid for local use + keratolytic agent.

Application Belosalik 15g ointment for external use during pregnancy and breastfeeding

Local use of the drug BELOSALIK® in pregnant women is allowed in cases where the expected benefit to the mother outweighs the risk to the fetus. In such cases, the use of the drug should be short-term and limited to small areas of the skin.

During breastfeeding, the use of BELOSALIK® is possible according to strict indications, but the drug cannot be applied to the skin of the mammary gland before feeding.

Use in pediatrics

The use of the drug BELOSALIK® in children should be short-term, subject to strict precautions, since in children there is a danger of systemic absorption of a proportionally larger amount of active components due to the predominance of skin area over body weight and insufficient maturity of the epidermis. The drug should not be used in children under bandages and, especially under plasticized diapers, as this may increase the risk of adverse events.

special instructions

Avoid contact with eyes and mucous membranes. Long-term use of the ointment on the skin of the face is not recommended due to the possible development of dermatitis such as rosacea, perioral dermatitis, skin atrophy and acne. Avoid using the drug in the anogenital area.

It is not recommended to use the drug under an occlusive dressing, except when necessary. If fungal or bacterial microflora develops on the skin, additional use of an antibacterial or antifungal agent is necessary.

INFLUENCE ON THE ABILITY TO DRIVE VEHICLES AND MECHANISMS

There is no data on the adverse effects of BELOSALIK® on the ability to drive vehicles and operate machinery.

Overdose

With long-term continuous use of a combination of betamethasone and salicylic acid, especially in children, on large surfaces of the skin, when applied to skin with impaired integrity or when used under an occlusive dressing, increased absorption of the active components and the manifestation of systemic effects (secondary adrenal insufficiency, hypercortisolism, syndrome) cannot be ruled out. Cushing). In this case, drug withdrawal and symptomatic therapy are recommended.

Side effects Belosalik 15g ointment for external use

Side effects are usually mild.

A hypersensitivity reaction (itching, burning or redness) may develop. Rarely, as with the use of other glucocorticosteroids, acne-like changes, hypopigmentation, stretch marks, skin atrophy, hypertrichosis, telangiectasia, and secondary skin infections may develop.

With long-term continuous use and over large areas of skin, topical use of betamethasone may cause systemic side effects associated with suppression of the function of the adrenal cortex.

If a hypersensitivity reaction or side effects occur, therapy should be discontinued and consult a doctor.

Drug interactions

There are no clinically significant interactions with other drugs. Simultaneous use of cosmetic and dermatological products for the treatment of acne, products containing ethanol, or medical soap with a pronounced drying effect, etc. may in certain cases cause skin irritation.

Side effects

Side effects are usually reversible and mild in nature.

From the skin: hypersensitivity reaction (itching, burning or redness), acne-like changes, hypopigmentation, stretch marks, skin atrophy, hypertrichosis, secondary skin infections.

With long-term continuous uncontrolled use and application to large areas of skin: telangiectasia, systemic manifestations of side effects of corticosteroids or salicylates.

If a hypersensitivity reaction or side effects occur, therapy should be discontinued and consult a doctor.

Directions for use and doses

Externally.

Bottle with spray nozzle

Belosalik® lotion is sprayed 2 times a day onto the affected areas of the scalp with hair, using a convenient elongated spray nozzle. In some cases, once a day is sufficient.

Before spraying, shake the bottle, place it in a vertical position, then bring the nozzle of the nozzle to the affected area of ​​skin with hair and press the sprayer all the way with your index finger. Apply the required number of sprays to the affected areas of the scalp.

The duration of the course of treatment is individual, as a rule, until the main symptoms of the disease disappear, but is usually limited to 3–4 weeks. If a longer course of therapy is necessary, it is recommended to use the drug less frequently, for example every other day, and consult a specialist.

Dropper bottle

Belosalik® lotion is used 2 times a day. A few drops of lotion are evenly distributed with a cotton swab or fingers over the surface of the skin, lightly rubbing. In some cases, once a day is sufficient. The duration of treatment is usually limited to 3–4 weeks. If a longer course of therapy is necessary, it is recommended to use the drug less frequently, for example every other day, or consult a specialist. Belosalik® lotion can be prescribed to children from 6 months of age with caution and for the shortest possible time.

Belosalik

Belosalik (betamethasone dipropionate + salicylic acid) is a two-component drug for external use in dermatological practice. Used for the treatment of eczematic skin lesions, psoriasis, hereditary keratinization disorders, chronic pruritic dermatosis, chronic allergic dermatitis, diffuse neurodermatitis, erythema multiforme with abundant exudation, dermatoses resistant to other glucocorticosteroids, dyshidrotic eczema, etc. Exhibits anti-inflammatory, vasoconstrictor, decongestant, antibacterial, antiallergic, fungicidal, antiproliferative, cooling, immunosuppressive, keratolytic effect. Prevents the release of cellular and plasma inflammatory mediators, suppresses the exudation and reproduction of cytokines, and prevents the migration of mononuclear phagocytes. The presence of salicylic acid in the composition of the drug softens the skin, eliminates keratinized scales and ensures deeper absorption of the glucocorticosteroid component through the skin. Belosalik ointment exhibits hydrophobic properties and forms a protective film that protects the skin from high humidity. Suitable for patients with dry skin. Belosalika lotion is easily applied to the skin, does not dry out hair, does not get dirty and has a hypothermic effect. Intended for external use only.

Frequency of use: 2-3 times a day. Can be used under an airtight bandage, which is changed once a day at regular intervals. An airtight bandage prevents the evaporation of sweat, resulting in the creation of conditions of high humidity, ensuring the softening of the stratum corneum of the skin and deeper absorption of the active components of the drug. The duration of the medication course is up to 21 days. If, according to indications, longer-term pharmacotherapy is necessary, then the drug is used not every day, but every other day. When treating chronic dermatological diseases, therapy is not stopped after the symptoms disappear, but is continued for some time to avoid relapses. Belosalik is contraindicated in case of individual intolerance to the components of the drug, infectious skin diseases caused by bacteria, viruses or fungi, rosacea, trophic ulcers, during pregnancy and breastfeeding. In pediatrics, the drug is used after the patient reaches one year of age. In this case, therapy is carried out with extreme caution due to the increased risk of absorption into the systemic circulation in childhood. Long-term use of Belosalik on the face is not recommended. In case of allergic rashes, the drug is discontinued. Belosalik should not be applied in close proximity to the eyes.

special instructions

Belosalik® lotion is intended for external use only.

Avoid contact with eyes and mucous membranes, as well as use of the drug in the anogenital area.

It is not recommended to use the drug under occlusive dressings, except when necessary. If fungal or bacterial microflora develops on the skin, additional use of an antibacterial or antifungal agent is necessary.

The drug Belosalik® lotion in the form of a solution for external use is especially convenient for use on the scalp. The solution is easily distributed over the surface of the skin, does not stick or dry out hair, does not leave visible marks, and has a cooling effect on the skin.

Impact on the ability to drive vehicles and machinery. There are no data on the adverse effects of Belosalik® lotion on the ability to drive vehicles and operate machinery.

Belosalik, ointment, 40 g

Manufacturer

Belupo, medicines and cosmetics d.d., Croatia

Compound

1 g of ointment contains:
Active substances:

betamethasone dipropionate - 640 mcg, which corresponds to the content of betamethasone - 500 mcg;

salicylic acid 30 mg.

Excipients:

mineral oil,

petrolatum.

pharmachologic effect

A drug with anti-inflammatory, antipruritic, antiproliferative, antimicrobial and keratolytic effects for external use.

Betamethasone has anti-inflammatory, antiallergic, antiproliferative and antipruritic effects.

When applied to the surface of the skin, betamethasone has a rapid and strong effect at the site of inflammation, reducing the severity of objective symptoms (erythema, swelling, lichenification) and subjective sensations (itching, irritation, pain).

Salicylic acid, due to its keratolytic action, cleanses affected areas of scales, promotes the penetration of betamethasone into the skin, maintains the acidic environment of the skin, preventing the development of bacterial and fungal infections.

Indications

Subacute and chronic dermatoses, for which therapy with topical corticosteroids is effective, and accompanied by hyperkeratosis and peeling, including:

• Psoriasis.
• Eczema (dyshidrotic, seborrheic, tylotic).
• Neurodermatitis.
• Lichen planus.
• Lichen asbestos.
• Chronic discoid lupus erythematosus.
• Ichthyosis and ichthyotic skin lesions.
• Seborrhea.
• Seborrheic dermatitis (scalp).

The drug in the form of a solution for external use is indicated for use on the scalp, as well as in children 6 months and older.

Use during pregnancy and breastfeeding

The use of the drug Belosalik (in the form of an ointment and/or solution for external use) in pregnant women is allowed in cases where the expected benefit to the mother outweighs the risk to the fetus.

In such cases, the use of the drug should be short-term and limited to small areas of the skin.

During breastfeeding, the use of Belosalik is possible according to strict indications, but the drug should not be applied to the skin of the mammary gland before feeding.

Contraindications

• Lupus.
• Skin manifestations of syphilis.
• Chicken pox.
• Viral skin infections.
• Skin post-vaccination reactions.
• Open wounds.
• Trophic ulcers.
• Rosacea.
• Acne vulgaris.
• Children up to 6 months (for ointment).
• Hypersensitivity to betamethasone, salicylic acid or any of the auxiliary components of the drug.

Side effects

Side effects are usually mild.

Dermatological reactions: possible development of hypersensitivity reactions (itching, burning, hyperemia); rarely - acne-like changes, hypopigmentation, striae, skin atrophy, hypertrichosis, telangiectasia, secondary skin infections.

With long-term continuous use and over large areas of skin: betamethasone can cause systemic adverse reactions associated with suppression of the function of the adrenal cortex.

If a hypersensitivity reaction or adverse reactions develop, the drug should be discontinued.

Interaction

No clinically significant interactions with other drugs were noted.

Simultaneous use of cosmetic and dermatological products

How to take, course of administration and dosage

The drug is intended for external use.

A small amount of ointment is evenly distributed over the surface of the skin, lightly rubbing. The frequency of use is 2 times a day; in mild cases, a single use is sufficient.

The duration of a continuous course of treatment is usually limited to 3-4 weeks. If a longer course of therapy is necessary, it is recommended to use the drug less frequently, for example, every other day.

When treating chronic diseases, treatment should be continued for some time after the disappearance of all symptoms, under the supervision of a doctor, to avoid relapse of the disease.

Repeated courses of therapy are possible throughout the year.

Special instructions

The ointment is intended for external use only on the skin and/or scalp.

Avoid contact of the ointment with the eyes and mucous membranes.

Long-term use of the ointment on the skin of the face is not recommended due to the possible development of dermatitis such as rosacea, perioral dermatitis, skin atrophy and acne.

Avoid using the drug in the anogenital area.

It is not recommended to use the drug under an occlusive dressing, except when necessary. If fungal or bacterial microflora develops on the skin, additional use of an antibacterial or antifungal agent is necessary.

Use in pediatrics

The use of the drug Belosalik in children should be as short as possible, subject to strict precautions, because in children, there is a danger of systemic absorption of a proportionally larger amount of active components due to the predominance of skin area over body weight and insufficient maturity of the epidermis. The drug should not be used in children under bandages and, especially under plasticized diapers, as this may increase the risk of adverse events.

Impact on the ability to drive vehicles and operate machinery

There is no data on the adverse effects of the drug Belosalik on the ability to drive vehicles and machines.

Release form

Ointment for external use.

Storage conditions

Store out of the reach of children at a temperature not exceeding 25°C.

Best before date

4 years.

Active substance

Betamethasone, Salicylic acid

Dosage form

ointment

Purpose

For adults, Children over 6 months, Pregnant women as prescribed by a doctor, Children as prescribed by a doctor, Nursing mothers as prescribed by a doctor

Indications

Allergy, Urticaria, Neurodermatitis, Psoriasis, Eczema, Dermatosis, Dermatitis

Barcode and weight

Barcode: 3850343001472 Weight: 0.054 kg