Comparison of the effectiveness of Skinoren and Effezel
Effezel is more effective than Skinoren - this means that the ability of the drug substance to provide the maximum possible effect is different.
For example, if the therapeutic effect of Effezel is more pronounced, then with Skinoren it is impossible to achieve this effect even in large doses.
Also, the speed of therapy is an indicator of the speed of the therapeutic action; Effezel and Skinoren are also different, as is bioavailability - the amount of a drug reaching the site of its action in the body. The higher the bioavailability, the less it will be lost during absorption and use by the body.
Effezel
The active substance is adapalene and benzoyl peroxide . Available in gel form for external use. The product is successfully used in the treatment of acne. The active components complement each other well.
Adapalene – has a pronounced anti-inflammatory effect. It is able to reduce the severity of inflammatory processes in acne. Benzoyl peroxide – has an antimicrobial effect. The substance normalizes sebum production and has an exfoliating effect.
The main indication is acne, in which there are pustules, comedones and papules.
Contraindications are an allergic reaction to the components included in the drug. It is also not recommended to use the product for children under 12 years of age, since studies of the drug for people of this age have not been conducted.
The gel is recommended to be applied to problem areas of the skin before bed. Noticeable results can be observed 1-4 weeks after regular use . If there is no effect or negative manifestations appear, you should stop using the drug.
Side effects include:
- Contact and allergic dermatitis.
- Dryness and flaking of the skin.
- Sunburn.
- Itching.
- Burning.
When the drug is discontinued, these symptoms go away on their own after 7 days and do not require additional therapy.
Comparison of safety of Skinoren and Effezel
The safety of a drug includes many factors.
At the same time, in Skinoren it is quite similar to Effezel. It is important where the drug is metabolized: drugs are excreted from the body either unchanged or in the form of products of their biochemical transformations. Metabolism occurs spontaneously, but most often involves major organs such as the liver, kidneys, lungs, skin, brain and others. When assessing metabolism in Skinoren, as well as in Effezel, we look at which organ is the metabolizing organ and how critical the effect on it is.
The risk-benefit ratio is when the prescription of a drug is undesirable, but justified under certain conditions and circumstances, with the obligatory observance of caution in use. At the same time, Skinoren does not have any risks when used, just like Effezel.
Also, when calculating safety, it is taken into account whether only allergic reactions occur or possible dysfunction of the main organs. In other matters, as well as the reversibility of the consequences of using Skinoren and Effezel.
When to use them
Most often, nootropics appear in the prescriptions of neurologists. They are prescribed for everything - from neurosis and OCD, from VSD, which does not exist, and dementia. In hospitals, nootropic drugs are administered intravenously to speed up tissue recovery after a stroke or transient ischemic attack - as prescribed by clinical recommendations. But they do not recommend using some nootropics during the acute period of ischemic stroke due to possible neuronal depletion and steal syndrome. Therefore, focusing only on them is not enough.
“First, the doctor makes a generally accepted diagnosis,” says GMS Clinic neurologist Sergei Makarov. — If we are talking about vascular cognitive impairment, then first of all the risk factors are corrected: diabetes mellitus, atherosclerosis and arterial hypertension. Not all diseases require medication."
But many neurologists and psychiatrists, who are not interested in new research, prescribe nootropics to people with impaired memory, attention and learning ability, focusing only on clinical recommendations. For example, Cerebrolysin is recommended for the prevention of dementia at the initial signs of Alzheimer's disease. Also, many doctors believe that nootropics will help you stay sane and memory longer in case of chronic vascular disorders of the brain.
“When a child has a disorder of psychoneurological development, the doctor is tempted to give something to “improve brain function,” says Varvara Khaletskaya, MD, neurologist at the Fantasy children’s clinic. “After all, sometimes there is no effective method leading to a complete recovery. Therefore, the doctor and the parent are trying to invest bit by bit: pedagogical correction, physiotherapy and medications.
It’s another matter when there is an effective treatment protocol, but the doctor continues to treat in his own way. It turns out ugly: instead of pedagogical correction, a child with psycho-speech disorders is given nootropic drugs, and they are advised to “wait” with classes. Or in the case of sensorineural hearing impairment, for which hearing aids are possible, they are referred to a neurologist to “feed” the auditory nerve. In this case, time is simply wasted. Before prescribing a treatment with insufficient evidence base, the doctor should make sure that there is a more effective solution.”
Comparison of addiction between Skinoren and Effezel
Like safety, addiction also involves many factors that must be considered when evaluating a drug.
So, the totality of the values of such parameters as “o syndrome” in Skinoren is quite similar to the similar values in Effezel. Withdrawal syndrome is a pathological condition that occurs after the cessation of intake of addictive or dependent substances into the body. And resistance is understood as initial immunity to a drug; in this it differs from addiction, when immunity to a drug develops over a certain period of time. The presence of resistance can only be stated if an attempt has been made to increase the dose of the drug to the maximum possible. At the same time, Skinoren’s “syndrome” values are quite small, just like Effezel’s.
Do they have any effect?
Until the 2000s, the actual mechanism of action and effectiveness of nootropics was not particularly studied. Doctors prescribed them, and people drank them. There was a myth circulating among medical students that a month-long course of nootropics before exams improves memorization of the material, and to be sure, you need to inject it into a muscle or vein.
Now the proof of the drug’s effectiveness is not the doctor’s word, but research data. There must be at least three thousand participants, and they must be divided into at least two groups, one of which is a control group with a placebo. At the same time, neither the doctor nor the patient knows what each of the subjects is drinking - medicine or a “dummy”.
Nootropic drugs have been little studied, and studies of their effectiveness are inadequate. Either there are too few people, or the criteria are unclear. For example, they estimate the number of test points only after treatment - they apparently forgot before treatment. The American FDA, in principle, does not consider nootropics to be drugs - in the USA they are sold as dietary supplements.
“Everyone knows that nootropics are drugs without proven effectiveness. But they continue to be used, says Varvara Khaletskaya. — There are statistics, there are international protocols that help the doctor. But at the same time, each doctor’s personal experience remains with a wide range: from “they are useless” to “they are effective in many patients.”
The fact is that there is a rare exception: piracetam improves cognitive function in people with severe dementia, according to an assessment of 19 high-quality studies. But with a traumatic brain injury or mild dementia, piracetam will no longer help. Moreover, it is useless for healthy people who want to follow the path of Eddie Morra from the film “Dark Areas” and become a megabrain. Therefore, if biohacking experiments with Mexidol seem to be effective, it is only due to self-persuasion.
Comparison of side effects of Skinoren and Effezel
Side effects or adverse events are any adverse medical event that occurs in a subject after administration of a drug.
Effezel has more adverse effects than Skinoren. This implies that the frequency of their occurrence is low in Effezel and low in Skinoren. Frequency of manifestation is an indicator of how many cases of an undesirable effect from treatment are possible and registered. The undesirable effect on the body, the strength of influence and the toxic effect of drugs are different: how quickly the body recovers after taking it and whether it recovers at all. When using Effezel, the body's ability to recover faster is higher than that of Skinoren.
What it is
These are drugs that improve performance, memory and learning ability. Piracetam was created first - it appeared in the sixties of the last century. In the seventies, scientist Corneliu Giurgia discovered that this medicine stabilizes the membranes of cells in the central nervous system, improving the functioning of brain cells. They didn’t know the exact mechanism of how piracetam works—they were just guessing. Giurja proposed using it to restore mental abilities after injuries, oxygen starvation of the brain, with senile dementia and congenital dementia in children.
Most nootropics are of animal origin. They are extracted from the brains of pigs and cattle, rich in low molecular weight proteins. The drugs are inexpensive and rarely cause side effects, which is why doctors love them.
Comparison of ease of use of Skinoren and Effezel
This includes dose selection taking into account various conditions and frequency of doses. At the same time, it is important not to forget about the release form of the drug; it is also important to take it into account when making an assessment.
The ease of use of Skinoren is approximately the same as that of Effezel. However, they are not convenient enough to use.
The drug ratings were compiled by experienced pharmacists who studied international research. The report is generated automatically.
Last update date: 2020-12-04 13:42:49
Baziron
The active ingredient is benzoyl peroxide . Available in gel form. Baziron has a pronounced antimicrobial effect. Also improves tissue oxygenation. Normalizes sebum production and promotes skin hydration.
The active substance is poorly absorbed into the skin and gradually turns into benzoic acid. It enters the bloodstream. It is excreted primarily by the kidneys. Does not accumulate in tissues.
The main indication is acne . It can also be used in the treatment of comedones without acne. The gel is also used in the treatment of trophic ulcers.
Contraindications are an allergic reaction to the constituent components, as well as children under 12 years of age.
The gel is applied to dry, clean skin on the affected areas. Usually 1-2 times a day . The duration of treatment should be at least three months. The therapeutic effect is observed no earlier than after 4 weeks of regular use . If necessary, the treatment course can be repeated after a certain time.
Sometimes, when applying a large amount of a substance, a number of side effects can develop. These include:
- Irritation and redness of the skin.
- Peeling.
- Itching.
- Burning sensation.
- Allergic reaction in the form of dermatitis, various rashes.
If these symptoms appear, you must stop using the drug. Typically, symptomatic therapy is not required, and the symptoms disappear on their own after a few days.
What to choose?
Skinoren is intended not only for the treatment of acne, blackheads and rosacea. It has a neutralizing effect on the very mechanisms of development of these formations.
The product is often used to maintain skin health after treatment with other drugs, as it helps prevent the appearance of spots after rashes and even out the color of the skin. The effect is noticeable after 2 - 4 weeks of regular use.
Differin is intended directly for the treatment of skin lesions - acne and closed comedones. Features of the use of the drug are as follows:
- long course of therapy - the first results will appear only several months after regular procedures;
- severe redness - the first two to three weeks the skin will get used to the new substance and react to it with dryness, redness and peeling;
- the need for repeated treatment - you need to understand that acne is considered a chronic disease and often after a course of therapy, acne appears again, and therapy has to be repeated;
- the ability to combine with other medications - treatment can be enhanced with other medications, including Skinoren.
Let us emphasize once again that Differin helps to cope with serious acne defects of the skin, and Skinoren is a reliable protection against spots and scars remaining in the place of cured acne and blackheads.
Release forms
The drugs Differin and Skinoren are available in two forms, which allows you to choose a medicine for any skin type. The gel-like consistency is recommended for use for oily and combination types of epithelium, and the cream for sensitive and dry ones.
If Skinoren contains different concentrations of the main active ingredient in different release forms - 150 mg and 200 mg per 1 gram of product, respectively, then the main component in 0.1% Differin gel and cream makes up the same proportion - 1 gram of base accounts for 1 mg of the active element.
Skinoren gel is produced in packages of 15, 30 and 50 grams, cream - 30 grams, Differin gel and cream - in plastic tubes of 30 grams.
