The healing process, recovery and consequences of condyloma removal


Genital warts in women (syn. - intimate papillomas, PVI, genital warts, venereal condylomatosis) are a group of viral infectious diseases characterized by the development of papillomatous formations on the skin and mucous membranes of intimate places.

Condylomas in gynecology are classified as diseases transmitted sexually, as well as through contact and household contact. Infection usually occurs during sex in the vagina, rectum, and less commonly through oral contact. A regular condom often does not become a barrier to HPV, since the size of the virus is much smaller than the size of the condom pore. HPV can only be transmitted from person to person. Self-propagation of formations throughout the body with the emergence of new foci is possible. In 50-70% of children born to infected mothers, vertical transmission of papillomavirus occurs.

HPV can persist for a certain time in exfoliating epithelial cells - therefore, for some diseases caused by this virus, a household route of infection (warts, intimate condylomas) is also likely, especially if there are microdamages to the skin. The widespread belief that these warts of the urogenital zone of any location can only be found in people who are sexually active or practicing other forms of intimate relationships is erroneous - they are often found in the intimate places of absolute virgins, children and teenage girls of different ages.

Condylomas in the labia (vulva) area

Vulvar condylomas appear as a result of infection with the human papillomavirus. This virus enters the female body more often during sexual intercourse. If the immune system is in good condition, this disease may not manifest itself for years, and a woman, not knowing that she is sick, can infect her partners with it if their local immune defense is insufficient. When immunity decreases, the virus can make itself felt. Condylomas may appear on the labia, internal genital organs, perineum, and anus.

Genital condylomas of the vulva must be removed without fail, and not only due to their lack of aesthetics, but given their growth and spread. This disease can progress and spread to the vaginal mucosa and cervix and to the skin of the anogenital area.

Treatment of condylomas should be carried out by a gynecologist, who will determine the treatment regimen.

Prevention

Strong immunity, hygiene and safe sex are the best prevention of infection with genital warts.

  • strengthening and maintaining the body’s defenses (immunity) at a high level;
  • maintaining a healthy lifestyle: good fortified diet, adequate sleep, moderate physical activity;
  • complete cessation of bad habits: smoking, alcohol, taking various medications;
  • If possible, avoid stressful situations, increase mental stability;
  • monitoring the general condition of the body, regular preventive examinations by doctors, laboratory diagnostics;
  • timely treatment and control of chronic diseases;
  • maintaining a sexual life with a regular partner, following the rules of contraception;
  • avoid injuring the skin of the penis and adjacent areas to avoid infection;
  • careful adherence to the rules of personal and intimate hygiene.

Compliance with medical recommendations and monitoring the state of the immune system prevents the development of viral activity and associated complications. The patient will get rid of the infection by carefully following the doctors' instructions, changing his lifestyle and streamlining his sex life. Self-medication in such cases is strictly contraindicated.

Treatment methods for condylomas in the labia (vulva) area

If you have condylomas on the vulva, you should immediately consult a gynecologist. Today, there are several approaches to the treatment of this disease, and an experienced professional, having established the correct diagnosis and assessed the extent of damage to the body, will be able to choose the correct treatment regimen.

As a rule, condylomas in the vulvar area are treated in the clinic in the following ways:

· excision with a scalpel;

· cryodestruction – cold treatment;

· the excision procedure is performed using laser or electrosurgical devices (radio wave apparatus with argon-enhanced coagulation).

Viral tumor specialists. Which doctor treats condylomas in men?

To check suspicious growths, you need to contact a dermatologist. This doctor specializes in skin diseases and growths. Including on the genitals.

There is nothing wrong with being examined by a doctor, so don’t put off diagnosis until too late. The sooner you are diagnosed, the sooner you will understand what to do about intimate warts.

Sometimes it's good to wait.

And in other cases, doctors recommend urgent surgery.

Each patient has a different situation.

Now you know which doctor treats genital warts in men and you can undergo a timely examination before dangerous complications arise. All that remains is to find a suitable medical center.

Vaginal condylomas

Condylomas in the vagina are also a consequence of infection with the human papillomavirus (HPV). The diagnosis is established by a gynecologist upon examination of the speculum of the vaginal mucosa, clarified during colposcopy, and confirmed by performing a PCR test for HPV and, in doubtful cases, taking a biopsy of the formation.

Condylomas in the vagina bring a lot of problems to a woman and can affect sexual behavior. Symptoms may include: the presence of growths in the vagina palpated by the woman herself during genital hygiene, an inflammatory reaction, itching, the appearance of cracks in the mucous membrane, pain during sexual intercourse.

This disease can progress and spread to the cervix, although it does not lead to cancer. Therefore, experts recommend treating condylomas in the vagina immediately after they are detected.

Contraindications to laser removal of genital warts

Removing genital warts with a laser has many advantages - this procedure does not cause pain and is performed in a short period of time. After healing, the formation of scars and scars is excluded. The laser beam acts precisely and does not injure surrounding tissues. No long-term rehabilitation is required.

Using the procedure, you can get rid of the discomfort caused by the tumor. Condyloma can become malignant; removing it reduces the risk of cancer. Traumatization of the growth leads to the fact that it becomes painful and inflammation appears.

Despite the effectiveness of laser removal of papillomas and condylomas, there are some limitations to the procedure. The doctor will be able to determine the possibility of performing the operation by conducting an examination, assessing the general health of the patient.

The procedure cannot be performed if the patient’s condition is serious, there is oncology or acute infectious diseases. Limitations may include the presence of autoimmune pathologies, blood clotting disorders, and various mental disorders. The advantage of using a laser is that growths are removed quickly and the likelihood of adverse reactions is minimal.

Treatment methods for vaginal condylomas

To remove tumors, the following destructive treatment methods are available:

· cryodestruction;

· laser removal, the most optimal destructive method;

Argon plasma ablation;

· radio wave (high frequency) removal, preferably with argon-enhanced coagulation.

Destructive methods of influence do not guarantee relapse of the disease, which is why the use of antiviral drugs is practiced in our country. Immunotherapy is not always justifiably used; more often it is prescribed blindly, without appropriate examination. This method sometimes gives side effects in the presence of condylomas, and as monotherapy it is ineffective, but in some cases it can give a good result, but this is impossible to predict. The best effect is achieved in a combination of destructive and conservative treatment.

Key points:

Treatment of condylomas of the external genitalia and vagina produces positive results in most patients within 1 to 6 months. At the same time, the virus can remain and be detected in 30% of women, without clinical manifestations, which no longer requires treatment, but observation.

It is important to note that condylomas that appear on new areas of the skin or mucous membrane during treatment or after completion of treatment do not require a change in treatment method. The appearance of new formations in the area where the treatment was carried out requires a change in the treatment method.

Patients should be informed about maintaining sexual rest during treatment and undergo examinations until the condylomas completely disappear.

Sexual partners should be examined and treated only if there are condylomas on the penis.

Cervical condylomas

Cervical condyloma is one of the types of HPV manifestations. Infection with this disease also occurs during sexual intercourse with an infected partner. In the absence of exophytic (visible) condylomas on the penis, the sexual partner may not be aware of the carriage of this virus.

Cervical condyloma is not always a consequence of HPV types 6 or 11. The cervix is ​​also affected by other types of viruses, which also have an oncogenic risk.

A special feature of condyloma on the neck is its shape. Condyloma can be flat and not visible when examined in a mirror, or it can be protruding (typical). Flat condyloma of the cervix is ​​detected during colposcopy. This painless technique involves examining the vulva, vagina and cervix under a microscope, stained with special solutions. Areas affected by flat condyloma are highlighted after staining with solutions.

To finally confirm the diagnosis, in addition to a cytological examination (Pap test), a PCR test for HPV and a biopsy or removal of the altered area with histological confirmation are performed.

It should be noted that any formation on the cervix, even a typical genital wart, after removal must undergo histological examination. If the gynecologist has no doubts about the diagnosis of cervical condyloma, then when using treatment methods after which it is not possible to conduct histology, it is necessary to take a biopsy before treatment.

Treatment of cervical condylomas

Removal of condylomas on the cervix is ​​a mandatory procedure in terms of the spread of infection and the prevention of cervical cancer.

Cervical condylomas can be removed in the following ways:

· laser vaporization is an effective technique with a low relapse rate and does not affect the reproductive function of nulliparous patients;

· argon plasma ablation – a good effect, especially in nulliparous patients;

· radio wave removal - a technique that allows a histological examination to be carried out after removal;

· cryodestruction is a popular method, but it is effective for small lesions;

· Solkovagin – cauterization of single genital warts using a chemical preparation.

Each of the listed methods has its own advantages and disadvantages. In each specific case, the choice of treatment remains with the doctor and depends on the availability of equipment and the qualifications of the specialist.

Using destructive treatment methods, part of the affected cervical tissue that is visible or detectable by colposcopy is removed, but not the virus itself. Therefore, along with removal, gynecologists recommend antiviral or immunomodulatory drugs of local or general action to prevent relapse and fight the virus. We cannot predict the effect of this treatment, but in some cases there is a positive result. It is incorrect to believe that antiviral drugs are the main ones in the fight against HPV. These medications activate the immune system, and it already resists viral aggression. In the practice of treating condylomas of any location, these drugs have their own niche of use. Clear evidence of the effectiveness of these dosage forms has not been obtained, so they are practically not used in world practice.

Vulvar condylomas during pregnancy

Pregnancy can provoke the development of exophytic condylomas (visible), which previously did not bother and did not make themselves felt. Condylomatosis is the result of the presence of the human papillomavirus in the body. This virus, having entered a woman’s body, may not manifest itself in any way if the immune system is strong. However, during pregnancy there is a temporary decrease in immunity due to the presence of a fetus, which half consists of foreign genetic material (protein) belonging to the husband. The papilloma virus, if present and in an inactive state, may begin to manifest itself in the form of neoplasms on the external and internal genital organs of a woman, in the perineum, and in the vicinity of the anus.

Condylomas during pregnancy must be removed due to their active growth and the sooner this is done, the better.

Treatment of condylomas during pregnancy should be carried out by an obstetrician-gynecologist who is fluent in removal techniques. Treatment of exophytic condylomas is preferable using the most effective modern laser and radio wave equipment with argon-enhanced coagulation. These operations are usually performed in a hospital under intravenous or epidural anesthesia. With extensive condylomatosis, removal is sometimes carried out in several stages. Epithelization of the wound surface in pregnant women occurs quite quickly, due to increased blood circulation in the genital area. Therefore, removal of condylomas can be carried out from early pregnancy up to 36 weeks of pregnancy. Before the planned removal of condylomas, it is necessary to conduct an examination to exclude possible complications occurring during pregnancy (for example, the threat of miscarriage, gestosis, etc.). Carry out sanitation in case of an inflammatory reaction in the genital area.

During pregnancy, only external condylomas should be removed. It is better not to touch condylomas in the vagina and cervix, as this is associated with an increased risk of bleeding and the threat of miscarriage. As practice shows, condylomas regress on their own after childbirth, especially in the vagina.

In pregnant women with condylomas, only local immunotherapy is performed. Virus carriage, without clinical manifestations (presence of visible condylomas), is not a basis for therapy. It is better to start treatment before removal and continue after surgery. The goal is to reduce the risk of recurrence of condylomas.

To ensure that you are not burdened by treatment for condylomas during pregnancy, it is preferable to undergo testing for the presence of HPV before planning a pregnancy. If this virus is detected, it is necessary to first improve the body’s defenses and only then plan a pregnancy. If this is not done, then there is a chance that you will develop condylomas during pregnancy.

It is not possible to guarantee that a woman will be cured of the virus before a planned pregnancy using modern medications. Treatment of the identified inflammatory process of the reproductive tract, before a planned pregnancy, is a sufficient measure to prevent exacerbation of HPV.

It should be emphasized that carriage of HPV of any type, without clinical manifestations (presence of exophytic condylomas), is not a contraindication to pregnancy.

Methods for destroying growths. How to get rid of genital warts in men

Not all patients seek urgent removal of genital warts - quite often the tumors do not cause discomfort and are almost invisible. Just a few tiny growths. They are not even felt.

Do they need to be removed?

Decide for yourself - although these genital warts don't bother you, they are still contagious and increase your chances of passing the virus on to your partner. You can wait until the genital warts disappear on their own. But most of these viral tumors disappear within only two years, and not all patients want to endure that long.

Therefore, let's return to treatment options.

In many cases, doctors first prescribe topical treatments—creams and ointments containing chemicals that slowly destroy the warts.

With this treatment, surgery is not necessary. However, there are also disadvantages - these remedies are not very effective and usually begin to work only with repeated use. So the therapy will continue for a long time. In addition, she has a high risk of recurrence of growths.

Operations are more reliable. They allow you to get rid of genital warts in men in almost all cases. Unfortunately, the guarantee is not 100%.

Basic procedures:

  • Cryotherapy

The doctor freezes the growth with liquid nitrogen. The tumor gradually dies and falls off, and new healthy skin grows under it. Sometimes several sessions are needed.

  • Surgical excision

The doctor cuts off genital warts with a scalpel or other instruments. Usually it also removes a thin layer of skin around the growths. For complete removal. After the operation, wounds remain, and then scars may appear.

  • Electrocoagulation

The doctor burns the tumor with high-frequency electric current. A small wound remains. It heals in a few weeks.

  • Laser therapy

The doctor removes condylomas with a beam of light. This method is well suited against growths that are difficult to remove with other methods. The wound from the operation becomes covered with a crust and heals completely in three weeks.

A little advice - do not sign up for surgery immediately when you discover genital warts.

Better go for a checkup. It is quite possible that genital warts will disappear without expensive treatment.

However, it is not worth delaying therapy for a long time - especially when various complications appear that make life with growths difficult. In such cases, you need the help of a doctor.

Childbirth with condylomatosis

I would like to remind you that condylomas themselves are a manifestation of the human papillomavirus (HPV). This virus may pose a risk of fetal infection and laryngeal papillomatosis in the unborn child. Research does not confirm that 100% of women who carry the virus become infected in the fetus. Unfortunately, it is impossible to predict whether a child will become infected with the virus during pregnancy and childbirth. Undoubtedly, the presence of condylomas increases the risk of infection, so it is better to remove the tumors.

The need for delivery by cesarean section in women with condylomatosis is decided individually. It is preferable to give birth on your own, even despite the presence of formations in the area of ​​the external or internal genital organs that are present before childbirth. There are cases that children born by cesarean section from pregnant women with HPV carriage suffer from laryngeal papillomatosis. Caesarean section is performed on pregnant women in the presence of extensive condylomatosis of the external genitalia, when this prevents vaginal delivery, or in combination with other complications and diseases during pregnancy.

It should be noted that termination of pregnancy for condylomatosis of the anogenital area is usually not performed.

Condylomas in the rectum (anus) area

Anal condylomas, like other types of similar neoplasms, are the result of infection of the body with the human papillomavirus. Condylomas in the anus are a rather complex disease, which is accompanied by the following symptoms:

  • the appearance of a formation in the anus;
  • an increase in the number of warts in this area;
  • traumatization of warts due to mechanical impact.

Condylomas of the rectum must be treated without fail. A specialized doctor who is able to correctly diagnose this disease is a proctologist. As soon as you experience one of the above unpleasant sensations, you should immediately consult a doctor. Condylomas in the anal area are also called perianal by experts.

Papillomavirus is transmitted through sexual intercourse. In this case, anal sex plays a role.

Provocateurs of appearance

Certain conditions are required for formations to appear.

These include:

  • Alcohol consumption;
  • Smoking;
  • Lack of proper nutrition;
  • Little physical activity;
  • Fatigue, psycho-emotional overload;
  • Neglect of hygiene;
  • Cracks in the skin of the genital organs;
  • Weak immunity;
  • Hormonal imbalance;
  • Lack of barrier contraception;
  • UV irradiation.

If several factors are present at once, this can accelerate the development of the disease.

Treatment of anal warts

Perianal condylomas require immediate treatment due to the many inconveniences they cause to the patient and the likely progression of the disease. Modern specialists, along with excision of formations using various methods, simultaneously influence the patient’s immune system.

Treatment of condyloma in the anal area will be effective if you contact a specialized specialist in a timely manner and strictly follow all his recommendations. Proper influence on the immune system of a patient with condylomatosis activates the body's defenses and directs all their efforts to fight the papilloma virus.

Factors of HPV progression are:

  • acute and exacerbation of chronic inflammatory diseases of the genital organs (trichomoniasis, chlamydia, mycoplasma genitalium, herpes simplex virus, etc.);
  • the presence and exacerbation of systemic diseases (diabetes mellitus, systemic lupus erythematosus, thyroid disease, etc.);
  • immunosuppressive therapy (for example, after organ transplantation);
  • hormonal disorders;
  • contraception (taking COCs for >5 years);
  • smoking;
  • stressful situations.

Treatment of condylomatosis at home

The main disadvantage of various destructive treatment methods is the recurrence of the disease, which varies, depending on the technique, from 20 to 50% of cases.

Imiquimod cream, commercial name Aldara, is a highly effective remedy in the fight against genital warts. This cream, when applied topically to the skin, acts as an immunomodulator, stimulating the production of interferons. This leads to a decrease and then to the disappearance of condylomas and a decrease in the amount of HPV in the tissue.

Aldara cream, available in sachets (sachets) for one-time use, is applied to condylomas and the skin near them 3 times a week before bed, and the next morning the area of ​​application is cleaned with soap and water. Treatment continues until the condylomas disappear, on average 4 weeks, but not more than 16 weeks. When used, a local skin reaction in the form of redness (erythema) may occur. In this situation, you can pause until the reaction disappears and continue treatment. More details about the method of use are described in the instructions for the Aldara cream.

Numerous clinical studies show that imiquimod (Aldara cream) can achieve significant improvement within 8-10 weeks of use. There is a low relapse rate of 13%. Additionally, it should be noted that the drug stimulates the regeneration of the skin and improves its appearance in case of actinic (senile) keratosis.

Complications of condylomatosis

Given that both sexes are equally susceptible to condylomatosis, this disease poses a greater danger for women than for men. Benign anogenital warts (condylomas), in 90% of cases are caused by HPV types 6 and 11 and are benign. Patients with visible warts can also be infected with highly oncogenic HPV types 16 and 18, which may be flat and not visible during routine examination. These last 2 types can cause cancer of the lower reproductive organs (cervix, vagina and vulva).

Genital warts caused by HPV types 6 and 11 are benign growths. Such neoplasms are not dangerous and cannot lead to oncological degeneration. They cause a lot of inconvenience to humans and pose a danger to sexual partners due to the high probability of infection.

Experts consider flat lesions more dangerous due to the difficulty of their timely diagnosis. It is viral lesions of the flat type that can cause tissue degeneration.

Buschke-Levenshtein condyloma is a fairly rare disease. Medical science does not have accurate statistical data due to the external similarity of this formation with epidermoid cancer.

In the initial stages, giant Buschke-Levenshtein condyloma appears in the form of elements similar to papillomas, wart-like nodules and genital warts. All elements of the neoplasm grow quickly, merge together, and form a tumor with a specific wide base. The surface of such a giant condyloma is characterized by growths and vegetations. All surface elements are separated by grooves. As the tumor grows, individual parts become more pronounced, becoming superficially covered with horny scales.

This is a rare type of disease associated with HPV types 6 and 11, characterized by aggressive growth.

Giant condylomas are usually localized in the anogenital area.

Features and diagnosis of giant condylomas

Giant Buschke-Levenshtein condyloma has a characteristic clinical feature: progressive growth. There is a pronounced tendency for recurrence of this disease, even after complete excision of the existing formation. Predominantly exophytic growth is observed against the background of the presence of invasive growth. The result is the fusion of individual parts of the new growth, which forms its external similarity to the cauliflower inflorescence.

Buschke-Levenshtein's condyloma, from the point of view of histological picture, is diverse: areas of benign condylomas alternate with areas of atypical cells or squamous cell carcinoma.

To confirm this diagnosis, specialists must carry out differential diagnosis, the purpose of which is to exclude the following probable diagnoses:

  • squamous cell carcinoma;
  • condyloma lata, which accompanies syphilis;
  • ordinary genital warts.

Difficulties in diagnosis may arise due to the transformation of giant or ordinary condyloma acuminata into an atypical tumor. The disease requires multiple sectional biopsies and computed tomography (CT) or magnetic resonance imaging (MRI).

To completely exclude oncology, complete excision of the tumor is performed with histological examination.

The difference between papilloma and condyloma

During life, a variety of formations appear on the human body. The most common benign formations include the following:

  • nevi;
  • papillomas;
  • warts;
  • others.

It should be understood that not all formations are safe. It is always preferable to consult a dermatologist to determine the danger of a particular skin formation.

Papillomas are delicate papillary formations on human skin that appear as a result of infection of the skin, most often with certain strains of the human papillomavirus (HPV). The virus is transmitted by contact from the skin of an infected person to the skin of an uninfected person. Papillomas can remain on a person’s body throughout his life; these tumors are considered safe. Dermatologists still strongly recommend removing papillomas due to the possibility of damaging them or accidentally tearing them off, which can lead to negative consequences.

Condyloma is a rough scallop formation on the skin and mucous membranes of the genital organs, anogenital area and oral cavity. Condylomatosis is a disease that is caused mainly by HPV types 6 and 11. In this case, the mode of transmission is sexual (sexual transmission). Condylomas (warts) develop as a result of a decrease in the body’s protective abilities, and are subject to mandatory removal, which is one of the stages of complex treatment of this problem.

The main difference between condyloma and papilloma is their location on the human body. Also, these neoplasms have different structural features. In any case, you should not engage in self-diagnosis and self-medication. If you are interested in an effective solution to the problem, it is preferable to contact a specialized specialist: in the genital area, this is a gynecologist, on the skin of another area, a dermatologist.

Prevention of condylomatosis

Condylomatosis is a consequence of infection of the body with the human papillomavirus (HPV), which is mainly transmitted through sexual contact. It appears in the form of warts called condylomas. Such formations can appear on the external and internal genital organs, in the anal area, and oral cavity.

Therefore, to prevent condylomatosis, you should avoid:

· presence of sexually transmitted infections;

· neglect of protective equipment during sexual intercourse;

· smoking;

· mechanical trauma to the skin or mucous membrane of the genital organs.

Symptoms

After infection with HPV, it may take several years for the first genital warts to appear. Often the infection occurs without symptoms, so it is impossible to confirm HPV infection without a laboratory test.

Symptoms of the development of viral warts:

  • at the initial stage - redness of the skin, small rash;
  • the appearance of flat warts on the mucous membranes of the genital organs;
  • discomfort during sex (pain, itching, burning);
  • the appearance of erosions and cracks in the genital area;
  • change in skin color of the perineum, hyperemia;
  • the appearance of single papillae on a filiform stalk.

After the first condylomas appear, the disease can develop according to the following scenarios:

  • self-healing after restoration of immunity (extremely rare);
  • active reproduction of warts;
  • stable remission (the number and size of formations are unchanged);
  • malignant transformation.

Any of these symptoms is a good reason for urgent consultation with a gynecologist and venereologist.

Self-regression of condylomas

The sexually active population can become infected with HPV during their lifetime; according to statistics, 80% of people are susceptible to this. The majority self-heal from HPV without clinical manifestations and without treatment. This occurs due to the activation of the local and general immunity of the infected person. In approximately 10% of patients, the virus has clinical manifestations, these include anogenital condylomas and patients with precancer and cervical cancer.

As practice shows, condylomas in pregnant women regress on their own after childbirth, especially in the vagina.

Behavior after removal of condylomas

Inform the patient that it may take 1 to 6 months for condylomas to disappear. During this time, relapses of the disease are possible, but a complete cure will still occur.

Reassure the patient that due to the long persistence of the virus after infection (the presence of the virus in the body in an inactive state), the appearance of condylomas in only one sexual partner in a permanent relationship does not mean sexual contact on the side of the other partner.

Smokers who do not respond well to treatment should quit smoking, as there is a link between smoking and genital warts.

Advise the use of a condom to reduce the risk of recurrent or additional infection.

It is recommended to avoid excessive solar radiation (tanning) and use sunscreen while vacationing in the south, since excessive sun exposure stimulates the development of the virus, if present in the body tissues.

Warn about the inappropriateness of various warm-ups (sauna, steam bath, hot bath), this can also provoke the activity of the human papillomavirus when carrying the virus.

Healing after removal of condylomas

After removal of condylomas, the resulting wounds are usually recommended to be treated with Baneocin powder. Accordingly, for some time there may be profuse serous or minor bleeding after removal of condylomas, which is absolutely normal and should not frighten the patient.

After removal of condylomas, swelling and pain may occur, which can last from two to five days. Their duration is related to the size of the removed tumors and the individual sensitivity of the person.

In most cases, during the healing process, itching may occur after removal of condylomas, which is also absolutely normal, as for the healing of any other area of ​​the skin.

After removal of condylomas, limit physical activity and exclude sexual activity for about 2-3 weeks until epithelization (healing) of the wound surface.

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